Mihir M Sanghvi

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Dendritic cells (DC) play a central role in antigen presentation and are often targeted by adenoviral (Ad)-based gene therapy. However, DC lack the coxsackie-Ad receptor, and little is known about the process by which they acquire and present Ad-encoded antigens. We examined the expression of alpha(v)beta3 integrins (CD51/CD61) on mouse bone marrow-derived(More)
The level of antigen loading can impact on the capacity for dendritic cells (DC) to activate T cell responses. Several different approaches to adenoviral (Ad)-based transduction were therefore assessed for their effect on both transgene expression and T cell activation. While a conventional E1(-)/E3Delta Ad vector (Ad/GFP) produced a concentration-dependent(More)
Image quality assessment is fundamental as it affects the level of confidence in any output obtained from image analysis. Clinical research imaging scans do not often come with an explicit evaluation of their quality, however reports are written associated to the patient/volunteer scans. This rich free-text documentation has the potential to provide(More)
BACKGROUND Cardiovascular magnetic resonance (CMR) is the gold standard method for the assessment of cardiac structure and function. Reference ranges permit differentiation between normal and pathological states. To date, this study is the largest to provide CMR specific reference ranges for left ventricular, right ventricular, left atrial and right atrial(More)
AIMS The UK Biobank is a large-scale population-based study utilising cardiovascular magnetic resonance (CMR) to generate measurements of atrial and ventricular structure and function. This study aimed to quantify the association between modifiable cardiovascular risk factors and cardiac morphology and function in individuals without known cardiovascular(More)
UK Biobank, a large cohort study, plans to acquire 100,000 cardiac MRI studies by 2020. Although fully-automated left ventricular (LV) analysis was performed in the original acquisition, this was not designed for unsupervised incorporation into epidemiological studies. We sought to evaluate automated LV mass and volume (Siemens syngo InlineVF versions D13A(More)
1 Logic and Intelligent Data Group, Department of Informatics, University of Oslo, Norway 2 Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Radcliffe Department of Medicine, University of Oxford, UK 3 William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, UK 4 Information(More)
INTRODUCTION Lupin allergy remains a significant cause of food-induced allergic reactivity and anaphylaxis. Previous work suggests a strong association with legume allergy and peanut allergy in particular. Both doctors and the public have little awareness of lupin as an allergen. CASE PRESENTATION Case 1 was a 41-year-old Caucasian woman without previous(More)
Background Manual left ventricular (LV) volumes and function analysis is time consuming and operator dependent. Automated and semi-automated LV analysis tools could be helpful, especially in high volume clinical and research centres. Inline VF (Siemens) is a fully-automated assessment tool performing LV volume analysis during scan acquisition. The aims of(More)
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