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I INTRODUCTION The recent emergence of novel network applications such as Gnutella, Freenet, and Napster has reincarnated the familiar peer-to-peer (P2P) architecture model of the original Internet in new and innovative ways in an effort to facilitate worldwide sharing of information [1]. As a result, there is an ever-increasing need for distributed(More)
MicroRNAs (miRNAs) are small non-coding RNAs of about 18-24 nucleotides in length that negatively regulate gene expression. Discovered only recently, it has become clear that they are involved in many biological processes such as developmental timing, differentiation and cell death. Data that connect miRNAs to various kinds of diseases, particularly cancer,(More)
In this paper we study the latency effects introduced in large scale internet applications. In particular, we study the effects of heterogeneous latency on reachability in decentralized, distributed networks operating under flooding protocols. We show that the standard protocol mechanisms of time-to-live (TTL) and unique message identification (UID), used(More)
File sharing is a very popular service provided by peer-to-peer (P2P) networks. In a P2P file-sharing network, users share files and issue queries to the network to find the locations of the files residing at other peer nodes. Due to factors such as large user base and use of query broadcast protocols, each node in the network receives many search queries(More)
Peer-to-peer overlay networks present new opportunities and challenges for achieving enhanced network functionality at the application level. In this paper we study the impact of point-to-point network latency on flooding broadcast operations in peer-to-peer overlay networks. We show that two standard protocol mechanisms, used to control the amount of(More)
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