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Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
From Genome to Regulatory Networks For biologists, having a genome in hand is only the beginning—much more investigation is still needed to characterize how the genome is used to help to produce aExpand
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Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative massExpand
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BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals
The interpretation of genome sequences requires reliable and standardized methods to assess protein function at high throughput. Here we describe a fast and reliable pipeline to study proteinExpand
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Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins
Division Machinery Tagged An international consortium of labs has been testing the feasibility of large-scale screening for insights into the function of mammalian proteins by expressing a taggedExpand
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Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans.
Regulation of gene expression by sequence-specific transcription factors is central to developmental programs and depends on the binding of transcription factors with target sites in the genome. ToExpand
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modENCODE Project Genome by the Caenorhabditis elegans Integrative Analysis of the
clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained byExpand
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Genome-Wide Identification of Binding Sites Defines Distinct Functions for Caenorhabditis elegans PHA-4/FOXA in Development and Environmental Response
Transcription factors are key components of regulatory networks that control development, as well as the response to environmental stimuli. We have established an experimental pipeline inExpand
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A Genome-Scale Resource for In Vivo Tag-Based Protein Function Exploration in C. elegans
Understanding the in vivo dynamics of protein localization and their physical interactions is important for many problems in biology. To enable systematic protein function interrogation in aExpand
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The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation.
Existing evidence indicates that SET2, the histone 3 lysine 36 methyltransferase of Saccharomyces cerevisiae, is a transcriptional repressor. Here we show by five main lines of evidence that SET2 isExpand
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Random and targeted transgene insertion in C. elegans using a modified Mosl transposon
We have generated a recombinant Mos1 transposon that can insert up to 45-kb transgenes into the Caenorhabditis elegans genome. The minimal Mos1 transposon (miniMos) is 550 bp long and inserts DNAExpand
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