Leo A. B. Joosten28
Jos W. M. van der Meer20
Frank L. van de Veerdonk14
Marije Oosting12
28Leo A. B. Joosten
20Jos W. M. van der Meer
14Frank L. van de Veerdonk
12Marije Oosting
12Bart-Jan Kullberg
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  • Gerben Ferwerda, Stephen E Girardin, Bart-Jan Kullberg, Lionel Le Bourhis, Dirk J. de Jong, Dennis M. L Langenberg +5 others
  • 2005
Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide. Recognition of M. tuberculosis by pattern recognition receptors is crucial for activation of both innate and adaptive immune responses. In the present study, we demonstrate that nucleotide-binding oligomerization domain 2 (NOD2) and Toll-like receptors (TLRs) are two(More)
  • Iñigo Olalde, Morten E Allentoft, Federico Sánchez-Quinto, Gabriel Santpere, Charleston W K Chiang, Michael DeGiorgio +18 others
  • 2014
Ancient genomic sequences have started to reveal the origin and the demographic impact of farmers from the Neolithic period spreading into Europe. The adoption of farming, stock breeding and sedentary societies during the Neolithic may have resulted in adaptive changes in genes associated with immunity and diet. However, the limited data available from(More)
  • Jeanette Wagener, R. K. Subbarao Malireddi, Megan D. Lenardon, Martin Köberle, Simon Vautier, Donna M. MacCallum +7 others
  • 2014
Chitin is an essential structural polysaccharide of fungal pathogens and parasites, but its role in human immune responses remains largely unknown. It is the second most abundant polysaccharide in nature after cellulose and its derivatives today are widely used for medical and industrial purposes. We analysed the immunological properties of purified chitin(More)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem, with 10 million new cases diagnosed each year. Innate immunity plays an important role in the host defense against M. tuberculosis, and the first step in this process is recognition of MTB by cells of the innate immune system. Several classes of pattern recognition(More)
The recent insight that inflammation contributes to the development of atherosclerosis and type 2 diabetes mellitus constitutes a major breakthrough in understanding the mechanisms underlying these conditions. In addition, it opens the way for new therapeutic approaches that might eventually decrease the prevalence of these public health problems. Tumor(More)
BACKGROUND Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system. METHODS AND FINDINGS In the present study, freshly obtained human peripheral blood mononuclear cells were stimulated(More)
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here by integrating transcriptional analysis and functional genomics, we identified Candida-specific host defence mechanisms in humans. Candida induced significant expression of genes from the type I(More)
  • Tania O. Crişan, Theo S. Plantinga, Frank L. van de Veerdonk, Marius F. Farcaş, Monique Stoffels, Bart-Jan Kullberg +3 others
  • 2011
Autophagy is a cell housekeeping mechanism that has recently received attention in relation to its effects on the immune response. Genetic studies have identified candidate loci for Crohn's disease susceptibility among autophagy genes, while experiments in murine macrophages from ATG16L1 deficient mice have shown that disruption of autophagy increases(More)
INTRODUCTION It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (SNPs) within the endotoxin receptor and its signaling system showed an association with the risk of disease development. This study aims to examine the response associated with(More)
Candida spp. are medically important fungi causing severe mucosal and life-threatening invasive infections, especially in immunocompromised hosts. However, not all individuals at risk develop Candida infections, and it is believed that genetic variation plays an important role in host susceptibility. On the one hand, severe fungal infections are associated(More)