Miguel Williams

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Digital PCR offers very high sensitivity compared to many other technologies for processing molecular detection assays. Herein, a process is outlined for determining the lower limit of detection (LoD) of two droplet-based digital PCR assays for point mutations of the epidermal growth factor receptor (EGFR) gene. Hydrolysis probe mutation-detection assays(More)
The virus recovered from cases of European brown hare syndrome in the U.K. contains one major capsid protein of approximately 60 k molecular weight and morphologically resembles known caliciviruses. It has been compared with a European isolate of rabbit haemorrhagic disease calicivirus and, although it shows some antigenic similarity, it is not identical.(More)
Data from physical and genetic mapping studies show that the vegetative genome of the temperate, Group E 1 Salmonella bacteriophage, ε15, is circularly-permuted. Preliminary evidence suggests that the circular permutation of the ε15 genome is non-random.
Targeted delivery of drugs and sensors into cells is an attractive technology with both medical and scientific applications. Existing delivery vehicles are generally limited by the complexity of their design, dependence on active transport, and inability to function within cellular compartments. Here, we developed self-assembled nanofibrous hydrogel fibers(More)
To a considerable degree, our knowledge of the cytochrome system in insects is based on the initial studies of Keilin (5, 6). Subsequently, in the absence of more detailed appraisal of this enzyme system in insects, two assumptions have seemed acceptable: (1) that the cytochrome system is of general distribution in the tissues of insects; and (2) that the(More)
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