Miguel Vaquero

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OBJECTIVE This study was undertaken to analyze whether nitric oxide (NO) modulates the human potassium channel hKv1.5, which generates the ultrarapid delayed rectifier current (IKur) that determines the height and duration of atrial action potentials. METHODS Currents were recorded using the whole-cell patch-clamp in Ltk- cells expressing hKv1.5 channels.(More)
  • Ricardo Gómez, Ricardo Caballero, Adriana Barana, Irene Amorós, Enrique Calvo, Juan Antonio López +14 others
  • 2009
Rationale: The cardiac inwardly rectifying K ؉ current (I K1) plays a critical role in modulating excitability by setting the resting membrane potential and shaping phase 3 of the cardiac action potential. Objective: This study aims to analyze the effects of nitric oxide (NO) on human atrial I K1 and on Kir2.1 channels, the major isoform of inwardly(More)
— Currently, the Modern Analog Technique (MAT) is one of the most used techniques in paleoceanography and it is applied for the quantitative reconstruction of environmental conditions of the past. Through the calculation of distances between modern and paleo data, patterns (analogs) are found, and after an interactive analysis, paleoenvironmental features(More)
Recent evidence has shown that the inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) might exert antiarrhythmic effects both in experimental models and in humans. In this study we analyzed the effects of atorvastatin and simvastatin acid (SVA) on the currents responsible for the duration of the plateau of human atrial action(More)
Rationale: The cardiac inwardly rectifying K ؉ current (I K1) plays a critical role in modulating excitability by setting the resting membrane potential and shaping phase 3 of the cardiac action potential. Objective: This study aims to analyze the effects of nitric oxide (NO) on human atrial I K1 and on Kir2.1 channels, the major isoform of inwardly(More)
— HESPERIA is an information system for helping in the collaborative research of a multidisciplinary group in the paleoclimatology field. While there exist international databases and information systems that provide long term storage of georeferenced data, they cannot be used during the research stage, since they are limited to published data. The system(More)
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