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BACKGROUND Multiple excitation wavelets are present during ventricular fibrillation (VF). The underlying wavelet organization of VF is unclear. Phase singularities (PSs)-locations of ambiguous activation state-underlie reentry and wavelet splitting and represent the sources of VF. Understanding the mechanisms of PS formation might be important in the(More)
BACKGROUND The past thirty-five years have seen an intense search for the molecular mechanisms underlying calcium-induced calcium-release (CICR) in cardiac myocytes, with voltage clamp (VC) studies being the leading tool employed. Several VC protocols including lowering of extracellular calcium to affect Ca²(+) loading of the sarcoplasmic reticulum (SR),(More)
Rate-dependent effects on the C a2+ sub-system in a rat ventricular myocyte are investigated. Here, we employ a deterministic mathematical model describing various C a2+ signalling pathways under voltage clamp (VC) conditions, to better understand the important role of calmodulin (CaM) in modulating the key control variables C a2+/calmodulin-dependent(More)
A perceived distinctive feature of cryoablation is the stability (cryoadherence) of the catheter tip during cold temperatures at the desired location, even during tachycardia. We report the case report of a young patient with a parahisian accessory pathway where stability of the ablation catheter was not achieved despite using the cryocatheter with a(More)
The objective of this study is to develop a comprehensive model of the electromechanical behavior of the rat ventricular myocyte to investigate the various factors influencing its contractile response. Here, we couple a model of C a2 + dynamics described in our previous work, with a well-known model of contractile mechanics developed by Rice, Wang, Bers and(More)
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