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BACKGROUND One of the greatest challenges in Metabolic Engineering is to develop quantitative models and algorithms to identify a set of genetic manipulations that will result in a microbial strain with a desirable metabolic phenotype which typically means having a high yield/productivity. This challenge is not only due to the inherent complexity of the(More)
The Multilayer Perceptrons (MLPs) are the most popular class of Neural Networks. When applying MLPs, the search for the ideal architecture is a crucial task, since it should should be complex enough to learn the input/output mapping, without overfitting the training data. Under this context, the use of Evolutionary Computation makes a promising global(More)
BACKGROUND Over the last few years a number of methods have been proposed for the phenotype simulation of microorganisms under different environmental and genetic conditions. These have been used as the basis to support the discovery of successful genetic modifications of the microbial metabolism to address industrial goals. However, the use of these(More)
Time Series Forecasting (TSF) allows the modeling of complex systems as " black-boxes " , being a focus of attention in several research arenas such as Operational Research, Statistics or Computer Science. Alternative TSF approaches emerged from the Artificial Intelligence arena, where optimization algorithms inspired on natural selection processes, such as(More)
This article presents three methods to forecast accurately the amount of traffic in TCP=IP based networks: a novel neural network ensemble approach and two important adapted time series methods (ARIMA and Holt-Winters). In order to assess their accuracy, several experiments were held using real-world data from two large Internet service providers. In(More)
The Genetic Algorithms (GAs) paradigm is being used increasingly in search and optimization problems. The method has shown to be efficient and robust in a considerable number of scientific domains, where the complexity and cardinality of the problems considered elected themselves as key factors to be taken into account. However, there are still some(More)
A large number of optimization problems within the field of Bioinformatics require methods able to handle its inherent complexity (e.g. NP-hard problems) and also demand increased computational efforts. In this context, the use of parallel architectures is a necessity. In this work, we propose ParJECoLi, a Java based library that offers a large set of(More)
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) threatens public health worldwide, and epidemiologic data suggest that the Panton-Valentine Leukocidin (PVL) expressed by most CA-MRSA strains could contribute to severe human infections, particularly in young and immunocompetent hosts. PVL is proposed to induce cytolysis or(More)