Miguel Castanho

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BACKGROUND AND PURPOSE Kyotorphin (KTP; L-Tyr-L-Arg), an endogenous neuropeptide, is potently analgesic when delivered directly to the central nervous system. Its weak analgesic effects after systemic administration have been explained by inability to cross the blood-brain barrier (BBB) and detract from the possible clinical use of KTP as an analgesic. In(More)
Patients diagnosed with Alzheimer's disease (AD) tend to underestimate their pain degree as disease progresses. Their caregivers are the most important source of information by providing regular pain evaluation. Our objectives were to compare pain intensity and affective pain between patients with AD and cognitively normal individuals (N) and to evaluate(More)
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