Miguel Ângelo Hyppolito

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INTRODUCTION Cisplatin is an effective chemotherapeutic agent commonly used in the treatment of malignant tumours, but ototoxicity is a significant side effect. OBJECTIVES To discuss the mechanisms of cisplatin ototoxicity and subsequent cell death, and to present the results of experimental studies. MATERIAL AND METHODS We conducted a systematic search(More)
Aminoglycoside antibiotics cause considerable toxicity to the inner ear. A progressive hearing loss at high frequencies resulted from the loss of hair cells in the base of the cochlea and a constant preoccupation with finding a treatment that protects against their toxic effects. A self-protection phenomenon to high ototoxic doses of gentamicin is proposed(More)
OBJECTIVES To determine the differences between tympanic and extratympanic electrodes regarding recording technique, comfort and ease of execution of the exam, and quality of auditory potential tracings. STUDY DESIGN Prospective cross-section investigation. METHODS Determination of the summation potential/action potential (SP/AP) ratio by(More)
UNLABELLED The most common etiologies of tympanic membrane perforation are infections and trauma. OBJECTIVE The objective of the present study was to assess the healing of traumatic tympanic membrane perforation in rats. METHODS The tympanic membrane from male Wistar rats was perforated in the anterior and posterior portions to the handle of the(More)
Cisplatin is a potent antineoplastic drug widely used for the treatment of cancer in both adults and children. One of its most important side effects is ototoxicity, which leads to irreversible bilateral hearing loss for high frequencies (4–8 kHz). Several studies have tried to identify drugs that, when combined with cisplatin, may act as otoprotectors. The(More)
BACKGROUND muscle strength and power are two factors affecting balance. The impact of muscle strength and power on postural control has not been fully explored among different age strata over sixty. OBJECTIVES the aim of the present study was to assess the muscle strength and power of elderly women in different age groups and determine their correlation(More)
acial nerve neurinoma is a rare entity, although of great nterest, especially from the point of view of the differntial diagnosis of the causes of peripheral facial palsy.1 eurinomas are benign tumors, derived from Schwann cells. hey manifest mainly as peripheral facial palsy, which can e slow, gradually affecting several nerve branches, or with sudden(More)
UNLABELLED Cisplatin is an antineoplastic drug for cancer treatment in children and adults. The side effects of cisplatin ototoxicity are significant: irreversible bilateral hearing damage to high frequencies (4 kHz - 8 kHz). Reports recognize some drugs that are associated with cisplatin to obtain an otoprotector effect. The ototoxicity mechanisms of(More)
UNLABELLED The use of animal samples is important in otologic research and understanding the anatomy of their ears help make proper use of them in research projects. AIM to study guinea pig's and rat's ears under light microscopy(LM) and scanning electron microscopy(SEM) and understand their anatomical advantages in basic otologic research. MATERIALS(More)
PURPOSE To compare the role of transitory latex and sylastic® implants in tympanoplasty on the closure of tympanic perforations. METHODS A randomized double-blind prospective study was conducted on 107 patients with chronic otitis media submitted to underlay tympanoplasty and divided at random into three groups: control with no transitory implant, latex(More)