Miguel-Ángel Maciá Martínez

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PURPOSE To evaluate three methods for digoxin dose adjustment in aged patients. METHODS We determined the plasma digoxin levels that would be attained in 87 old patients with doses adjusted to the kidney function by means of three separate procedures. RESULTS Age: 79.0 "6.3 years of age; creatinin clearance (Clc): 0.70" 0.23 ml/Kg of lean body weight(More)
OBJECTIVES A retrospective economic evaluation was performed on the restriction of the use of piroxicam in Spain, a non-steroidal anti-inflammatory drug, with a proven higher risk of serious gastrointestinal complications compared to other non-steroidal anti-inflammatory drugs with the objective of putting the relevance of these activities into context. (More)
BACKGROUND Comparison of efficacy and safety of four highly active antiretroviral therapy regimens (HAART) including two nucleoside analogues (NA) and a protease inhibitor (PI) in HIV positive patients with advanced infection and antiretroviral naive. PATIENTS AND METHODS Multicenter, randomized and open labeled clinical trial in ten community hospitals(More)
OBJECTIVE To clarify if there is any basis for the hypothesis that Clebopride leads to more extrapyramidal reactions than Metoclopramide. DESIGN Observational, longitudinal, retrospective and comparative study of two series of cases. SETTING The entire Spanish healthcare system. PATIENTS Those notified to the Spanish Drug watch system as possibly(More)
PURPOSE To evaluate three methods for digoxin dose adjustment in aged patients. METHODS We determined the plasma digoxin levels that would be attained in 47 consecutive old patients with doses adjusted to the creatinin clearance (Clc) by means of three mathematical functions. RESULTS Age: 79.1 +/- 6.1 years of age; Clc: 0.77 +/- 0.24 mL/kg of lean body(More)
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