Mieke de Jager

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Cerebral amyloid angiopathy (CAA) is a key histopathological hallmark of Alzheimer's disease (AD) and hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D). CAA is characterized by amyloid-beta (Aβ) depositions and remodeling of the extracellular matrix (ECM) in brain vessels and plays an important role in the development and(More)
Cover image: immunofluorescence staining of tTG (green) and tTG activity (red) in a brain blood vessel of the APP23 Alzheimer mouse model as used in Chapter 5. APP23 mice are originally from healthcare company Novartis. Image printed with permission of Novartis. Chapter images: immunofluorescence stainings of collagen (green) in culture plates after removal(More)
Ilona B. Bruinsma,1,2 Mieke de Jager,1,2 Anna Carrano,5 Alexandra A. M. Versleijen,1,2 Robert Veerhuis,6 Wilbert Boelens,3 Annemieke J. M. Rozemuller,5 Robert M. W. de Waal,4 and Marcel M. Verbeek1,2 Departments of 1Neurology and Alzheimer Centre, 2Laboratory Medicine, 3Biomolecular Chemistry and Nijmegen Centre for Molecular Life Sciences, and 4Pathology,(More)
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