Mieke Zeinstra-Smith

  • Citations Per Year
Learn More
BACKGROUND Reticular basement membrane (RBM) thickening has been variably associated with asthma and chronic obstructive pulmonary disease (COPD). Even if RBM thickness is similar in both diseases, its composition might still differ. OBJECTIVE To assess whether RBM thickness and composition differ between asthma and COPD. METHODS We investigated 24(More)
Tumor-targeting of anticancer drugs is an interesting approach for the treatment of cancer since chemotherapies possess several adverse effects. In the present study, we propose a novel strategy to deliver anticancer drugs to the tumor cells through the mannose-6-phosphate/insulin-like growth factor receptor (M6P/IGF-IIR) which are abundantly expressed in(More)
INTRODUCTION Most patients with asthma and many patients with COPD show bronchial hyperresponsiveness to adenosine (BHR(AMP)). BHR(AMP) may be caused by release of mast cell histamine, which induces smooth muscle contraction. AIM OF THE STUDY To evaluate whether mast cell numbers in airway smooth muscle are increased in patients with asthma and COPD(More)
  • 1