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SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation.
VCP/p97 is involved in a variety of cellular processes, including membrane fusion and ubiquitin-dependent protein degradation. It has been suggested that adaptor proteins such as p47 and Ufd1p conferExpand
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Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion.
Assessing in vitro cellular responses to molecular events is an effective mean to elucidate the toxicological behavior of the ultrafine nanoparticles. In this study, we utilized the DNA microarrayExpand
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Reliable size determination of nanoparticles using dynamic light scattering method for in vitro toxicology assessment.
Dynamic light scattering (DLS) is widely used for the evaluation of the particle size in the toxicity assessment of nanoparticles. However, the many types of DLS instruments and analytical proceduresExpand
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Dispersion characteristics of various metal oxide secondary nanoparticles in culture medium for in vitro toxicology assessment.
The aim of this study is to characterize the dispersion characteristics of various metal oxide nanoparticles and secondary nanoparticle formation in culture medium. Many studies have alreadyExpand
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Development of an in vitro photosensitization assay using human monocyte-derived cells.
In this study, with the aim of developing a cell-based in vitro photosensitization assay, we examined whether changes of CD86 and CD54 expression on cells of a human monocytic cell line, THP-1, couldExpand
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Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells.
p38 mitogen-activated protein kinase (MAPK) has a crucial role in the maturation of dendritic cells (DCs) by sensitizers. Recently, it has been reported that the oxidation of cell surface thiols byExpand
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Synthesis and central nervous system actions of thyrotropin-releasing hormone analogs containing a 1-oxo-1,2,3,4-tetrahydroisoquinoline moiety.
In order to find compounds having selective central nervous system (CNS) actions, various thyrotropin-releasing hormone (TRH) analogs in which the pyroglutamic acid residue is replaced byExpand
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Evaluation of changes of cell-surface thiols as a new biomarker for in vitro sensitization test.
In order to find a novel biomarker for a simple assay to predict skin sensitization, we evaluated cell-surface thiols as a biomarker reflecting intracellular signaling in THP-1 cells (human monocyticExpand
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Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100 nm or less.
Even though there have been some investigations into cellular responses induced by ultrafine titanium dioxide (TiO(2)) in vitro, the relationship between cellular responses and secondary particleExpand
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Enhancement of paraquat toxicity by glutathione depletion in mice in vivo and in vitro.
Effect of glutathione (GSH) depletion on paraquat (PQ) toxicity in the liver and kidneys of mice was examined. Glutamic-pyruvate transaminase (GPT) and blood urea nitrogen (BUN) levels in plasma ofExpand
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