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Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells
It is shown that the expression of oncogenically mutated ras gene induces cellular degeneration accompanied by cytoplasmic vacuoles in human glioma and gastric cancer cell lines, and the activation of the non-apoptotic cell death program may become a potential cancer therapy complementing apoptosis-based therapies.
Fructan 1-Exohydrolases. β-(2,1)-Trimmers during Graminan Biosynthesis in Stems of Wheat? Purification, Characterization, Mass Mapping, and Cloning of Two Fructan 1-Exohydrolase Isoforms1,212
Cl cloning, purification, and characterization of two fructan 1-exohydrolase cDNAs (1-FEH w1 andw2) from winter wheat stems are reported on, revealing that inulin-type fructans [β-(2,1)] are much better substrates than levan- type fructANS [β-2,6]; both enzymes are highly identical (98% identity).
Carbohydrate levels among winter wheat cultivars varying in freezing tolerance and snow mold resistance during autumn and winter
The LT50 values and soluble carbohydrate levels in wheat crowns and leaves were monitored throughout autumn and winter in cultivars varying in freezing tolerance and snow mold resistance and suggested that the enzymatic metabolism of the synthesis of sugars and the conversion of fructan to cryoprotective sugars in response to low temperatures might be different between the two contrasting types in resistance to winter stress.
Genetic engineering of rice capable of synthesizing fructans and enhancing chilling tolerance.
The results suggest that transgenic rice lines expressing wheat-derived fructosyltransferase genes accumulated large amounts of fructans in mature leaf blades and exhibited enhanced chilling tolerance at the seedling stage, the first report owing that fructan accumulation enhanced tolerance to non-freezing low temperatures.
Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction.
- D. Yahia, M. A. El-Nasser, S. Tsuda
- Medicine, BiologyThe Journal of toxicological sciences
- 1 August 2010
It is found that PFOS exposure to mice during pregnancy led to intracranial blood vessel dilatation of fetuses accompanied by severe lung collapse which caused neonatal mortality, which adopted the corresponding experimental design to PFOS in order to characterize the neonatal death by PFOA.
Molecular Characterization of Sucrose:Sucrose 1-Fructosyltransferase and Sucrose:Fructan 6-Fructosyltransferase Associated with Fructan Accumulation in Winter Wheat during Cold Hardening
- A. Kawakami, Midori Yoshida
- Medicine, BiologyBioscience, biotechnology, and biochemistry
- 1 January 2002
Wft1 and Wft2 were important in fructan accumulation during cold hardening of winter wheat, and showed that the level of wft2 transcripts increased from autumn to early winter in the crown tissues of all field-grown wheat cultivars examined.
Coordinated expression of functionally diverse fructosyltransferase genes is associated with fructan accumulation in response to low temperature in perennial ryegrass.
At least two different patterns of gene expression have developed during the evolution of functionally diverse FT genes, which are associated in a coordinated way with fructan synthesis in a cold environment.
Low temperature-wheat-fungal interactions: A carbohydrate connection
An understanding of the metabolism of soluble carbohydrates, particularly fructans, during plant growth, hardening, and snow mold infection, is essential to the elucidation of survival mechanisms in plants subjected to these winter stresses.
Collaborative work on evaluation of ovarian toxicity by repeated-dose and fertility studies in female rats.
A validation study intended to evaluate whether a 2-week repeated general toxicity period with histopathological examination is sufficient to detect ovarian toxicity found that it may be sufficient, except for cytotoxic compounds such as alkylating agents.
Maternal exposure to low doses of bisphenol a has no effects on development of female reproductive tract and uterine carcinogenesis in Donryu rats.
- Midori Yoshida, T. Shimomoto, Sayumi Katashima, G. Watanabe, K. Taya, A. Maekawa
- BiologyThe Journal of reproduction and development
- 1 June 2004
The results demonstrate that maternal exposure to BPA at levels comparable to human exposure did not have any effects on the female reproductive system of offspring in rats.