• Publications
  • Influence
Cloning and Functional Characterization of a Novel ATP-sensitive Potassium Channel Ubiquitously Expressed in Rat Tissues, including Pancreatic Islets, Pituitary, Skeletal Muscle, and Heart (*)
ATP-sensitive K (K) channels play a crucial role in coupling metabolic energy to the membrane potential of cells. We have isolated a cDNA encoding a novel member (uK-1) of the inward rectifier KExpand
  • 392
  • 25
Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide belonging to the vasoactive intestinal polypeptide/glucagon/secretin family. It is widely distributed in the body, and aExpand
  • 239
  • 13
Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells.
Synaptotagmin (p65), an integral membrane protein of synaptic vesicles, is thought to be involved in calcium-dependent exocytosis of synaptic vesicles. Here, we report the cloning and tissueExpand
  • 139
  • 7
Cellular localization of synaptotagmin I, II, and III mRNAs in the central nervous system and pituitary and adrenal glands of the rat
Three isoforms of synaptotagmin, a synaptic vesicle protein involved in neurotransmitter release, have been characterized in the rat, although functional differences between these isoforms have notExpand
  • 99
  • 5
Localization and Functional Role of Synaptotagmin III in Insulin Secretory Vesicles in Pancreatic β-Cells
Pancreatic β-cells secrete insulin by Ca2+-triggered exocytosis of insulin-containing large dense-core vesicles. Synaptotagmin is a Ca2+/phospholipid-binding protein and is a good candidate for theExpand
  • 62
  • 4
Noc2, a Putative Zinc Finger Protein Involved in Exocytosis in Endocrine Cells*
We have cloned a cDNA encoding a novel protein of 302 amino acids (designated Noc2, no C2 domain) that has 40.7% amino acid identity with and 77.9% similarity to the N-terminal region ofExpand
  • 78
  • 3
Cloning of a mouse Rabphilin-3A expressed in hormone-secreting cells.
Rab3A, a ras p21-related small GTP-binding protein, is implicated in the exocytosis of neurotransmitters. Recently, Rabphilin-3A, a putative target protein for Rab3A, was identified and its cDNA hasExpand
  • 27
  • 3
Molecular Visualization of Immunoglobulin Switch Region RNA/DNA Complex by Atomic Force Microscope*
Immunoglobulin heavy-chain (IgH) class switch recombination (CSR) is initiated by DNA breakage in the switch (S) region featuring tandem repetitive nucleotide sequences. Various studies haveExpand
  • 43
  • 1
  • PDF
RAG2 Is Down-regulated by Cytoplasmic Sequestration and Ubiquitin-dependent Degradation*
Periodic accumulation and degradation of RAG2 (recombination-activating gene 2) protein controls the cell-cycle-dependent V(D)J recombination of lymphocyte antigen receptor genes. Here we show theExpand
  • 41
  • 1
Action of apoptotic endonuclease DNase γ on naked DNA and chromatin substrates
Abstract The internucleosomal cleavage of genomic DNA is a biochemical hallmark of apoptosis. DNase γ, a Mg2+/Ca2+-dependent endonuclease, has been suggested to be one of the apoptotic endonucleases,Expand
  • 22
  • 1