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Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology
The cell cycle inhibitor p21CDKN1A is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The main, well-knownExpand
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Berberine: new perspectives for old remedies.
Chemical compounds derived from plants have been used since the origin of human beings to counteract a number of diseases. Among them, the natural isoquinoline alkaloid berberine has been employed inExpand
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CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis
The proliferating cell nuclear antigen (PCNA) protein serves as a molecular platform recruiting and coordinating the activity of factors involved in multiple deoxyribonucleic acid (DNA) transactions.Expand
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Berberine, an Epiphany Against Cancer
Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism.Expand
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PARP inhibitors: new tools to protect from inflammation.
Poly(ADP-ribosylation) consists in the conversion of β-NAD(+) into ADP-ribose, which is then bound to acceptor proteins and further used to form polymers of variable length and structure. The correctExpand
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p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1.
The cell cycle inhibitor p21(CDKN1A) has been shown to participate in nucleotide excision repair by interacting with PCNA. Here we have investigated whether p21 plays a role in base excision repairExpand
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p300/CBP acetyl transferases interact with and acetylate the nucleotide excision repair factor XPG.
Nucleotide excision repair (NER) is an important DNA repair mechanism through which cells remove bulky DNA lesions. Following DNA damage, the histone acetyltransferase (HAT) p300 (also referred to asExpand
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Defective DNA repair and increased chromatin binding of DNA repair factors in Down syndrome fibroblasts.
Down syndrome (DS) is characterized by genetic instability, neurodegeneration, and premature aging. However, the molecular mechanisms leading to this phenotype are not yet well understood. Here, weExpand
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Killing of tumor cells: a drama in two acts.
Cancer still represents a major health problem worldwide, which urges the development of more effective strategies. Resistance to chemotherapy, a major obstacle for cancer eradication, is mainlyExpand
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Multiple Effects of Berberine Derivatives on Colon Cancer Cells
The pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploitExpand
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