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- Micol Tillhon, Luis Miguel Guamán Ortiz, Paolo Lombardi, Anna Ivana Scovassi
- Biochemical pharmacology
- 2012
Chemical compounds derived from plants have been used since the origin of human beings to counteract a number of diseases. Among them, the natural isoquinoline alkaloid berberine has been employed in… (More)
- Luis Miguel Guamán Ortiz, Paolo Lombardi, Micol Tillhon, Anna Ivana Scovassi
- Molecules
- 2014
Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism.… (More)
- Ornella Cazzalini, Francesca Donà , +6 authors Ennio Prosperi
- DNA repair
- 2010
The cell cycle inhibitor p21(CDKN1A) has been shown to participate in nucleotide excision repair by interacting with PCNA. Here we have investigated whether p21 plays a role in base excision repair… (More)
- Ilaria Dutto, Micol Tillhon, Ornella Cazzalini, Lucia Anna Stivala, Ennio Prosperi
- Archives of Toxicology
- 2014
The cell cycle inhibitor p21CDKN1A is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The main, well-known… (More)
- Ornella Cazzalini, Sabrina Sommatis, +9 authors Ennio Prosperi
- Nucleic acids research
- 2014
The proliferating cell nuclear antigen (PCNA) protein serves as a molecular platform recruiting and coordinating the activity of factors involved in multiple deoxyribonucleic acid (DNA) transactions.… (More)
- Vincenzo Giansanti, Francesca Donà , Micol Tillhon, Anna Ivana Scovassi
- Biochemical pharmacology
- 2010
Poly(ADP-ribosylation) consists in the conversion of β-NAD(+) into ADP-ribose, which is then bound to acceptor proteins and further used to form polymers of variable length and structure. The correct… (More)
- Micol Tillhon, Ornella Cazzalini, +5 authors Ennio Prosperi
- DNA repair
- 2012
Nucleotide excision repair (NER) is an important DNA repair mechanism through which cells remove bulky DNA lesions. Following DNA damage, the histone acetyltransferase (HAT) p300 (also referred to as… (More)
- Vincenzo Giansanti, Micol Tillhon, Giuliano Mazzini, Ennio Prosperi, Paolo Lombardi, Anna Ivana Scovassi
- Biochemical pharmacology
- 2011
Cancer still represents a major health problem worldwide, which urges the development of more effective strategies. Resistance to chemotherapy, a major obstacle for cancer eradication, is mainly… (More)
- Michele Parks, Micol Tillhon, Francesca Donà , Ennio Prosperi, Anna Ivana Scovassi
- Molecular and cellular endocrinology
- 2011
Colon carcinoma represents a major problem in oncology, since this type of cancer responds poorly to conventional chemotherapy. Many groups are actively involved in the search of new experimental… (More)
- Daniela Necchi, Antonella Pinto, +6 authors Ennio Prosperi
- Mutation research
- 2015
Down syndrome (DS) is characterized by genetic instability, neurodegeneration, and premature aging. However, the molecular mechanisms leading to this phenotype are not yet well understood. Here, we… (More)