Mickaël Tobalem

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Diabetic patients are at risk for spontaneous foot ulcers, chronic wounds, infections, and tissue necrosis. Current theories suggest that the development and progression of diabetic foot ulcers are mainly caused by arteriosclerosis and peripheral neuropathy. Tissue necrosis plays a primordial role in the progression of diabetic foot ulcers but the(More)
OBJECTIVE To investigate whether systemic erythropoietin administration can prevent secondary burn progression in an experimental model and to elucidate the underlying mechanisms. DESIGN Prospective study. SETTING University-based laboratory research. SUBJECTS Twenty-one male Wistar rats. INTERVENTIONS The burn comb model creates four rectangular(More)
BACKGROUND Damage control is essential in first aid of burn lesions. The aim of the present study was to investigate whether systemic erythropoietin (EPO) administration could prevent secondary burn progression in an experimental model. METHODS The burn comb model creates four rectangular burn surfaces intercalated by three unburned zones prone to(More)
BACKGROUND Hyperglycemia is known to adversely affect the outcome of ischemic insults, but its interaction with ischemia has not been investigated in wound repair yet. In this study, we develop a new animal model allowing to investigate the interaction between hyperglycemia and ischemia during the wound repair process. We focus on myofibroblast(More)
Recent findings have attested the protective effects of erythropoietin (EPO) in ischemically challenged organs. We therefore aimed at elaborating the underlying mechanism of EPO-mediated protection in musculocutaneous tissue undergoing persistent ischemia after acute injury. Mice were assigned to five experimental groups equipped with a randomly perfused(More)
University Hospitals of Geneva Geneva, Switzerland mickaeltobalem@gmail.com A n obese 50-year-old man with no known medical history presented with a necrotizing infection of his right foot that had begun 10 days previously with lesions that he attributed to wearing new shoes. He was found to have diabetes (glycated hemoglobin level, 10.5%) with peripheral(More)
INTRODUCTION First aid treatment for thermal injuries with cold water removes heat and decreases inflammation. However, perfusion in the ischemic zone surrounding the coagulated core can be compromised by cold-induced vasoconstriction and favor burn progression. The aim of this study is to evaluate the effect of local warming on burn progression in the rat(More)
BACKGROUND Complete implant coverage by pectoralis major muscle in immediate breast reconstruction prevents implant exposure but restricts implant volume, increases the risk of a high-riding implant, and prevents natural ptosis. The authors hypothesized that extension of the subpectoral pocket with Vicryl mesh may produce more satisfactory results. The(More)
BACKGROUND Shockwave (SW) application has been shown to limit flap necrosis. However, the underlying microhemodynamic mechanisms remain unclear. Therefore, the objective of this study was to analyze the effect of SW application on a microcirculatory level. METHODS We treated 12 C57BL/6 mice with local SW application (500 shockwave impulses at 0.15(More)
Dear Editor, We report the case of an apparently healthy young woman found unconscious in a sauna suffering from heat stroke syndrome (GCS score 3/15; core temperature 41.9 C; BP 80/60, pulse 160/min). She was immediately treated with external surface cooling, initially using towels soaked with ice packs (*20 min) followed by cold wet blankets (*40 min),(More)
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