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Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.
It is shown that during IRF8-dependent monocyte differentiation, IRf8 binding occurs at both promoter-proximal and promotor-distal regions together with the transcription factor PU and is associated with gene induction. Expand
IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils.
- D. Kurotaki, Michio Yamamoto, +10 authors T. Tamura
- Biology, Medicine
- Nature communications
- 19 September 2014
Irf8(-/-) haematopoietic progenitors not only bestows monocyte and DC differentiation potential upon mononuclear phagocytes but also restrains these progenitor from differentiating into neutrophils. Expand
Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development
It is shown that IRF4 has activities similar to IRF8 in regulating myeloid cell development, and it is demonstrated that Irf8 -/- Irf4 -/- mice exhibit a more severe chronic myeloids leukemia (CML)-like disease than IrF8 -/+ mice, involving a disproportionate expansion of granulocytes at the expense of monocytes/macrophages. Expand
The transcription factor IRF8 counteracts BCR-ABL to rescue dendritic cell development in chronic myelogenous leukemia.
It is shown that BCR-ABL strongly inhibits a generation of dendritic cells from an early stage of their differentiation in vivo, concomitant with suppression of Irf8 expression, suggesting that IRF8 is an attractive target in next-generation therapies for CML. Expand
Molecular and Cellular Pathobiology The Transcription Factor IRF 8 Counteracts BCR-ABL to Rescue Dendritic Cell Development in Chronic Myelogenous Leukemia
BCR-ABL tyrosine kinase inhibitors (TKI) have dramatically improved therapy for chronic myelogenous leukemia (CML). However, several problems leading to TKI resistance still impede a complete cure of… Expand
PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS Essential role of the IRF 8-KLF 4 transcription factor cascade in murine monocyte differentiation
• IRF8 induces the Klf4 gene in myeloid progenitors; this transcription factor cascade is essential for Ly6C monocyte development. • IRF8 binding to genomic targets promotes H3K4me1, a chromatin… Expand
154 : The IRF8-KLF4 transcription factor cascade is essential for the development of monocytes
It is concluded that the IRF8-KLF4 transcription factor cascade is essential for monocyte development. Expand
IRF8 inhibits the activity of C/EBPα to restrain mononuclear phagocyte progenitors from differentiating into neutrophils
275 : The transcription factor IRF8 overrides BCR-ABL to rescue dendritic cell development in chronic myeloid leukemia
It is shown that BCR-ABL strongly inhibits generation of DCs from an early stage of their differentiation in vivo, concomitant with suppression of Irf8 expression, suggesting that IRF8 is an attractive target in next-generation therapies for CML. Expand
PS2-016. Selective regulation of monocyte subsets by the transcription factor Interferon Regulatory Factor 8