Michio Kitajima

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OBJECTIVE To investigate the distribution of macrophage (Mphi) infiltration in eutopic and ectopic endometrium throughout the menstrual cycle. DESIGN Controlled clinical study using intact tissue. SETTING Nagasaki University School of Medicine, Nagasaki, Japan. PATIENT(S) Twenty infertile women with pelvic endometriosis and 20 women without(More)
OBJECTIVE To investigate the mitogenic and angiogenic activity of the eutopic and ectopic endometrium throughout the menstrual cycle and to examine whether the activity of the eutopic endometrium is useful to predict greater activity of the ectopic endometrium. DESIGN Controlled clinicopathologic study using intact tissue. SETTING Nagasaki University(More)
BACKGROUND Information is limited regarding the multifunctional role of GnRH agonist (GnRHa) therapy in reproductive diseases. We investigated the pattern of changes in inflammatory reaction, micro-vessel density and apoptosis in the tissues collected from women with endometriosis, adenomyosis and uterine myoma who were treated with or without GnRHa(More)
OBJECTIVE To determine whether elevated midpregnancy maternal serum lipid levels predict newborn weight at term and the risk of large for gestational age (LGA) infants in women with positive diabetic screen but normal glucose tolerance test. METHODS Japanese gravidas who had positive diabetic screens and normal 75-g oral glucose tolerance tests (GTT) at(More)
BACKGROUND The different macromolecules as secreted by macrophages in the pelvic environment are believed to enhance the growth of endometriosis. However, the possible mediator that stimulates macrophages for the production of different growth factors is not well described. Therefore, we investigated the possible production of hepatocyte growth factor (HGF)(More)
BACKGROUND Although intraepithelial lymphocytes (IELs) in human oviductal epithelium have been implicated in the regulation of local immunity, the precise kinetics and mechanism of steroid regulation of IEL are largely unknown. METHODS We examined the localization of estrogen receptors (ERs) and progesterone receptors (PRs) in 41 human oviducts by(More)
BACKGROUND The purpose of this work was to investigate whether clinical cytology could be useful in the preoperative diagnosis of pelvic actinomycosis. METHODS This study involved the prospective collection of samples derived from the endometrium and the uterine cervix, and retrospective data analysis. Nine patients with clinically diagnosed pelvic(More)
OBJECTIVE To evaluate the adverse effects of endometriomas on ovarian reserve. DESIGN Analysis of prospectively collected biopsy samples. SETTING Gynecology research unit in a university hospital. PATIENT(S) Women younger than age 35 years with endometriomas. INTERVENTION(S) Biopsy of normal cortex from ovaries affected by endometriomas (≤4 cm) and(More)
BACKGROUND We investigated the expression of the hepatocyte growth factor (HGF) gene and protein by the stromal cells derived from women with or without endometriosis and its regulation by interleukin-6 (IL-6) and tumour necrosis factor alpha (TNFalpha). METHODS Stromal cells immunoreactive to vimentin were isolated from the eutopic and ectopic(More)
BACKGROUND Information regarding macrophage-mediated regulation of hepatocyte growth factor (HGF) by ovarian steroid hormones in women with endometriosis is limited. Therefore, we investigated the regulation of HGF by steroid hormones in isolated macrophages and stromal cells derived from women with or without endometriosis. METHODS We isolated CD68(More)