Michiko Watanabe

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Analyses of form-function relationships during heart looping are directly related to technological advances. Recent advances in four-dimensional optical coherence tomography (OCT) permit observations of cardiac dynamics at high-speed acquisition rates and high resolution. Real-time observation of the avian stage 13 looping heart reveals that interactions(More)
Corpus based studies of spontaneous speech showed that filled pauses tended to precede relatively long and complex constituents. We examined whether listeners made use of such a tendency in speech processing. We tested the hypothesis that when listeners heard filled pauses they tended to expect a relatively long and complex phrase to follow. In the(More)
Accurate imaging and measurement of hemodynamic forces is vital for investigating how physical forces acting on the embryonic heart are transduced and influence developmental pathways. Of particular importance is blood flow-induced shear stress, which influences gene expression by endothelial cells and potentially leads to congenital heart defects through(More)
Hesitations are prevalent in spontaneous speech and believed to be relevant to on-line speech planning. We tested the complexity hypothesis that speakers are more likely to need to suspend speaking, the more complex the constituent, by examining ratios of filled pauses (fillers) at clause and case boundaries with following constituents of different degrees(More)
Disfluencies are intrinsic in spontaneous speech. Although it is known that there is a wide range of frequencies and types of disfluencies among speech, little is known about factors affecting speakers ¶ choice of disfluency types. We first conducted a correspondence analysis using ratios of seven types of fillers, and other disfluencies, in 174(More)
Recently, we found that mutation of the C-terminus of transcription factor hexamethylene bisacetamide-inducible protein 1 (HEXIM1) in mice leads to abnormalities in cardiovascular development because of aberrant vascular endothelial growth factor (VEGF) expression. HEXIM1 regulation of some genes has also been shown to be positive transcription elongation(More)
Disturbed cardiac function at an early stage of development has been shown to correlate with cellular/molecular, structural as well as functional cardiac anomalies at later stages culminating in the congenital heart defects (CHDs) that present at birth. While our knowledge of cellular and molecular steps in cardiac development is growing rapidly, our(More)