Michiko Kandori

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H uman herpesvirus 7 (HHV-7), a common virus of the subfamily of -herpesviruses like cytomegalovirus (CMV) and HHV-6, was isolated initially from peripheral blood cells in adults. It causes ubiquitous infection in children as well as exanthema subitum. However, HHV-7–related ocular manifestations have not been reported. We describe a patient with unilateral(More)
PURPOSE To assess corneal scrapings and aqueous humor samples analyzed by polymerase chain reaction (PCR) that were positive for cytomegalovirus (CMV) in patients with keratitis of unknown origin and to investigate their clinical manifestations. DESIGN Retrospective, interventional case series. PARTICIPANTS Seventy-eight patients with epithelial (n=37),(More)
PURPOSE To characterize the cytomegalovirus-associated anterior segment inflammation and to determine whether the number of cytomegalovirus is significantly correlated with the disease characteristics. METHODS Retrospective consecutive case series. Seventy-three patients with refractory anterior segment inflammation due to iridocyclitis, corneal(More)
AIMS The purpose of this study is to elucidate the clinical manifestations and the current treatment status of cytomegalovirus (CMV) endotheliitis via a large case series obtained from a national survey conducted in Japan. METHODS The Japan Corneal Endotheliitis Study Group proposed diagnostic criteria for CMV endotheliitis based on a viral examination by(More)
PURPOSE To report 4 cases of Acanthamoeba keratitis treated with excimer laser phototherapeutic keratectomy (PTK) and to discuss the clinical efficacy of this procedure. METHODS Four cases with early stage Acanthamoeba keratitis resistant to medical amoebic therapy for at least 1 week and with an enlarged abscess underwent PTK. RESULTS After PTK, the(More)
PURPOSE To report 2 cases of Acanthamoeba keratitis whose causative pathogen was detected only by real-time polymerase chain reaction (PCR). METHODS Histological examinations of corneal scrapings were stained with Fungiflora Y. Corneal scrapings were also cultured on nonnutrient agar. Real-time PCR analyses of corneal scrapings were also performed. (More)
AIMS To determine the efficacy of a new helicase-primase inhibitor, ASP2151, for treating herpetic keratitis. METHODS Murine corneas were infected with herpes simplex virus type 1 (HSV-1). ASP2151 was administered orally or topically, and the severity of epithelial dendritic keratitis was determined. The effectiveness of ASP2151 was compared with that of(More)
BACKGROUND Corneal endothelial cells are known to be targets of herpes simplex virus type 1 (HSV-1) infection; however, the pathogenesis of HSV infections of the endothelial cells has not been definitively determined. The purpose of this study was to examine an unrecognised strategy of corneal endothelial cells to protect themselves from HSV-1 infection. (More)
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