Michihiro Tanaka

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The identification of orthologous genes in an increasing number of fully sequenced genomes is a challenging issue in recent genome science. Here we present KEGG OC (http://www.genome.jp/tools/oc/), a novel database of ortholog clusters (OCs). The current version of KEGG OC contains 1 176 030 OCs, obtained by clustering 8 357 175 genes in 2112 complete(More)
Duchenne muscular dystrophy (DMD) is a severe muscle-degenerative disease caused by a mutation in the dystrophin gene. Genetic correction of patient-derived induced pluripotent stem cells (iPSCs) by TALENs or CRISPR-Cas9 holds promise for DMD gene therapy; however, the safety of such nuclease treatment must be determined. Using a unique k-mer database, we(More)
Oleaginous photosynthetic organisms such as microalgae are promising sources for biofuel production through the generation of carbon-neutral sustainable energy. However, the metabolic mechanisms driving high-rate lipid production in these oleaginous organisms remain unclear, thus impeding efforts to improve productivity through genetic modifications. We(More)
Recent evidence points to the existence of scale-free properties in many biological networks. By topological analysis, several models including preferential attachment and hierarchical modules have been proposed to explain how these networks are organized. On the other hand, analyses using dynamics have suggested that gene expression and metabolic networks(More)
Hongmei Lisa Li,1 Naoko Fujimoto,1,2 Noriko Sasakawa,1 Saya Shirai,1 Tokiko Ohkame,1 Tetsushi Sakuma,4 Michihiro Tanaka,1 Naoki Amano,1 Akira Watanabe,1 Hidetoshi Sakurai,1 Takashi Yamamoto,4 Shinya Yamanaka,1,2,5 and Akitsu Hotta1,2,3,* 1Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan 2iCeMS, Kyoto University, Kyoto(More)
In the post-human genomic era, more and more other genomes have been sequenced. Comparative genomic analysis gives us an opportunity to find out the similarities and differences among different organisms. Moreover, comparative analysis of metabolic pathway can give us important information on their evolution and potential pharmacological targets. In this(More)
Glycerophospholipids are major structural lipids in cellular membrane systems and play key roles as suppliers of the first and second messengers in the signal transduction and molecular recognition processes. The distribution of lipid components differs among organelles and cells. The distribution is controlled by two pathways in lipid metabolism: de nova(More)
Various tissues possess tissue-specific stem/progenitor cells, including the inner ears. Stem/progenitor cells of the inner ear can be isolated as so-called otospheres from differentiated cells using a sphere forming assay. Although recent studies have demonstrated the characteristics of otospheres to some extent, most of the features of these cells are(More)
Fistulifera sp. strain JPCC DA0580 is a newly sequenced pennate diatom that is capable of simultaneously growing and accumulating lipids. This is a unique trait, not found in other related microalgae so far. It is able to accumulate between 40 to 60% of its cell weight in lipids, making it a strong candidate for the production of biofuel. To investigate(More)
Lipid mediator is the collective term for prostanoids, leukotrienes, lysophospholipids, platelet-activating factor, endocannabinoids and other bioactive lipids, that are involved in various physiological functions including inflammation, immune regulation and cellular development. They act by binding to their ligand-specific G-protein coupled receptors(More)
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