Michiharu Ishizaki

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In order to optimize collagen antigen unmasking in paraffin-embedded tissue sections, the effects of various fixatives and duration of fixation in relation to enzyme pretreatment and microwave irradiation for collagen antigen unmasking were studied. A streptavidin--biotin-- peroxidase complex method was used for the immunolocalization of type III and IV(More)
To elucidate the mechanisms of renal tubular dilatation in acute tubular necrosis (ATN), morphological findings after 60 min ischaemia were studied in rats. The characteristics of the tubular basement membrane (BM) were also examined. A morphometric analysis of cell proliferation, epithelial cellularity and the circumference of damaged tubules was(More)
Histamine H2-receptor antagonists administered into the central nervous system have been shown to increase arterial pressure (AP) in anaesthetized animals (Paakkari et al., 1982). Few studies have been reported on the effects of centrally administered cimetidine (CIM), one of the histamine H2-receptor antagonists, in conscious animals. However, the(More)
BACKGROUND Cytokines play an important role in chronic allergic eye disease. OBJECTIVES We examined how many kinds of cytokines are in giant papillae of vernal keratoconjunctivitis(VKC). METHODS We resected giant papillae from 6 patients with VKC, and studied mRNA expression of cytokines in them with the reverse transcriptase-polymerase chain(More)
PURPOSE To evaluate the anti-allergic effect of iodine in an allergic conjunctivities model. METHODS Guinea pigs (n = 107) were administered iodine at three different concentrations in feed. Twenty Guinea pigs were passively sensitized by serum containing ovalbumin (OA) antibody, and eighteen Guinea pigs were actively sensitized by OA intraperitoneal(More)
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