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A model is developed to describe neuronal elongation as a result of the polymerization of microtubules and elastic stretching of the neurites by force produced by the growth cone. The model for a single segment with a single growth cone revealed a constant elongation rate, while the concentration of tubulin in the soma rises, and the concentration of(More)
A basic but neglected property of neuronal trees is their finite length. This finite length restricts the length of a segment to a certain maximum. The implications of the finite length of the tree with respect to the segment length distributions of terminal and intermediate segments are shown by means of a stochastic model. In the model it is assumed that(More)
We have experimentally quantified exposure to dichloromethane during non-professional paint stripping and validated the mathematical paint exposure model of van Veen et al. (1999). The model innovates the prediction of the dichloromethane evaporation rate and room concentration by accounting for transport in the paint stripper matrix. The experiments show(More)
To describe the evaporation of organic solvents from paints and the resulting indoor concentrations, a mathematical model and an indoor paint experiment are presented. The model describes painting in terms of an increasing area of paint during application and two compartments of paint once applied. Evaporation of organic solvents is driven by the vapor(More)
Neuroblastoma is a pediatric embryonal malignancy characterized by impaired neuronal differentiation. A better understanding of neuroblastoma differentiation is essential for developing new therapeutic approaches. GDE2 (encoded by GDPD5) is a six-transmembrane-domain glycerophosphodiesterase that promotes embryonic neurogenesis. We find that high GDPD5(More)
Little information is available on product use by consumers, which severely hampers exposure estimation for consumer products. This article describes actual contact with several consumer products, specifically dishwashing detergents, cleaning products, and hair styling products. How and where products are handled, as well as the duration, frequency, and(More)
Consumer products may contain constituents that warrant a risk analysis if they raise toxicological concern. Risk assessments are performed a priori, e.g. for pesticides and biocides, and a posteriori, to diagnose risks of contaminants. An overview is presented of residential exposure assessment and risk characterization. For exposure assessment, predictive(More)
The tetranuclear aggregate (enH(2))[Fe(4)(mu(3)-O)(heidi)(4)(mu-O,O'-O(2)CNHC(2)H(4)NH(3))] x 4H(2)O contains a novel bidentate zwitterionic carbamic acid ligand. Magnetic studies indicate that the unsymmetrical Fe(4) core is ferrimagnetic with an S=4 ground state. Similar ligands have been obtained on rectangular tetranuclear aggregates(More)
  • M P van Veen
  • 1996
To assess exposure to and uptake of chemical compounds from consumer products, a general model framework is proposed. The model framework separates exposure into the components contact, potential exposure, and potential uptake rate, and establishes the relation between the three. It adds a contact function and a spatial component to other exposure modeling(More)