Michiel Holtkamp

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BACKGROUND Breast cancer cells deficient for BRCA1 are hypersensitive to agents inducing DNA double-strand breaks (DSB), such as bifunctional alkylators and platinum agents. Earlier, we had developed a comparative genomic hybridisation (CGH) classifier based on BRCA1-mutated breast cancers. We hypothesised that this BRCA1-like(CGH) classifier could also(More)
In 29 chemotherapy-naive patients with stage II-III breast cancer, peripheral blood stem cells (PBSCs) were mobilised following fluorouracil 500 mg m-2, epirubicin 90-120 mg m-2 and cyclophosphamide 500 mg m-2 (FEC) and granulocyte colony-stimulating factor (G-CSF; Filgrastim) 300 microgram s.c. daily. In all but one patient, mobilisation was successful,(More)
The prognosis of patients with stage IIIB breast carcinoma with tumour spread to the apical axillary lymph nodes has hardly improved despite adequate locoregional control and the introduction of systemic adjuvant therapy. A combined modality regimen that includes anthracyclin-based chemotherapy, high-dose chemotherapy with peripheral stem cell support and(More)
—This paper describes the use of a novel A * path-planning algorithm for performing line segmentation of handwritten documents. The novelty of the proposed approach lies in the use of a smart combination of simple soft cost functions that allows an artificial agent to compute paths separating the upper and lower text fields. The use of soft cost functions(More)
In our experiment a robot has to be able to localise itself by recognising a previously seen location. First the robot has to collect a set of images for every location, covering the complete surroundings of the robot. From these images distinguishing features will be extracted using sift (Scale Invariant Feature Transform). These features will be saved in(More)
High-dose chemotherapy (HD-CT) has a role in the potentially curative treatment of several tumours. The relative efficacies of the different regimens have not been studied in comparative trials, but it is clear that toxicities differ significantly between them. We analysed the immediate and long-term toxicity in the first 100 consecutive patients treated(More)
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