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- Nard Kubben, Michiel E. Adriaens, Wouter Meuleman, Jan Willem Voncken, Bas van Steensel, Tom Misteli
- Chromosoma
- 2012
Mutations in the A-type lamins A and C, two major components of the nuclear lamina, cause a large group of phenotypically diverse diseases collectively referred to as laminopathies. These conditions… (More)
- Twan van den Beucken, Elizabeth Koch, +16 authors Bradly G. Wouters
- Nature communications
- 2014
MicroRNAs are small regulatory RNAs that post transcriptionally control gene expression. Reduced expression of DICER, the enzyme involved in microRNA processing, is frequently observed in cancer and… (More)
- Marjukka Kolehmainen, Otto T. Mykkänen, +11 authors Riitta Törrönen
- Molecular nutrition & food research
- 2012
SCOPE
Low-grade inflammation is a hallmark of cardiometabolic risk. Bilberries (Vaccinium myrtillus) are rich in polyphenols with potential anti-inflammatory properties. We studied the impact of… (More)
- Andrea Romano, Michiel E. Adriaens, +4 authors Patrick G Groothuis
- Molecular and Cellular Endocrinology
- 2010
Tamoxifen and 17beta-estradiol are capable of up-regulating the expression of some genes and down-regulate the expression of others simultaneously in the same cell. In addition, tamoxifen shows… (More)
- Malou van den Boogaard, Scott Smemo, +18 authors Ivan P Moskowitz
- The Journal of clinical investigation
- 2014
Variants in SCN10A, which encodes a voltage-gated sodium channel, are associated with alterations of cardiac conduction parameters and the cardiac rhythm disorder Brugada syndrome; however, it is… (More)
- Richard J. Orton, Michiel E. Adriaens, Amelie Gormand, Oliver E. Sturm, Walter Kolch, David R. Gilbert
- BMC Systems Biology
- 2009
The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell signalling pathway that relays the signal for a cell to proliferate from… (More)
- Heather J. Cordell, Jamie R Bentham, +38 authors Bernard D Keavney
- Nature Genetics
- 2013
We carried out a genome-wide association study (GWAS) of congenital heart disease (CHD). Our discovery cohort comprised 1,995 CHD cases and 5,159 controls and included affected individuals from each… (More)
- Peggy Prickaerts, Hanneke E. C. Niessen, +9 authors Jan Willem Voncken
- Epigenetics & Chromatin
- 2012
Gene-environment interactions are mediated by epigenetic mechanisms. Polycomb Group proteins constitute part of an epigenetic cellular transcriptional memory system that is subject to dynamic… (More)
- Peggy Prickaerts, Michiel E. Adriaens, +8 authors Jan Willem Voncken
- Epigenetics & Chromatin
- 2016
Trimethylation at histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) controls gene activity during development and differentiation. Whether H3K4me3 and H3K27me3 changes dynamically in response to… (More)
- Lars M. T. Eijssen, Magali Jaillard, +4 authors Chris T. A. Evelo
- Nucleic Acids Research
- 2013
Quality control (QC) is crucial for any scientific method producing data. Applying adequate QC introduces new challenges in the genomics field where large amounts of data are produced with complex… (More)