Michiel A. van Agtmael

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OBJECTIVES HIV-infected patients using combination antiretroviral therapy (ART) have an increased cardiovascular risk. We aimed to identify the effects of HIV, ART, and lipodystrophy (LD) on carotid artery intima-media thickness (C-IMT), a surrogate measure of atherosclerosis, and arterial stiffness, a marker of cardiovascular risk. DESIGN Case-control(More)
The contribution of the enzymes CYP2D6 and CYP2C19 to the metabolism of artemether was evaluated in a cross-over study in seven healthy adult Caucasian subjects. The pharmacokinetic properties of artemether and its active metabolite dihydroartemisinin were compared when given 100 mg artemether orally alone or in combination with either CYP2D6-inhibitor(More)
Objective: To evaluate the effect of grapefruit juice on the pharmacokinetics of artemether in plasma and saliva after a single oral dose and to detect concentration-dependent electrocardiographic changes (bradycardia and QTc prolongation). Methods: Six healthy male subjects were given a standard breakfast followed by two tablets of 50-mg artemether(More)
The aim of this study is to evaluate the effect of different levels of realism of context learning on the prescribing competencies of medical students during the clinical clerkship in internal medicine. Between 2001 and 2007, 164 medical students took part in the prospective explorative study during their clinical clerkship in internal medicine at the VU(More)
Objective To investigate whether a dog’s superior olfactory sensitivity can be used to detect Clostridium difficile in stool samples and hospital patients. Design Proof of principle study, using a case-control design. Setting Two large Dutch teaching hospitals. Participants A 2 year old beagle trained to identify the smell of C difficile and tested on 300(More)
Systemic nocardiosis is most often caused by Nocardia asteroides, but it can also be caused by other Nocardia spp. with different antimicrobial susceptibility patterns. Difficulties in species determination and susceptibility testing can hamper the implementation of appropriate antibiotic therapy, as illustrated by the case reported here. In August 2003, a(More)
Dear Editor, The famous physician William Osler once wrote: ‘It is much more important to know what sort of a patient has a disease than what sort of a disease a patient has’. Although this statement was written in the late nineteenth century, inattention to the patient context is still a frequent and under-recognized cause of medical errors [1]. Especially(More)
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