Michiel A. van Agtmael

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OBJECTIVE To investigate whether a dog's superior olfactory sensitivity can be used to detect Clostridium difficile in stool samples and hospital patients. DESIGN Proof of principle study, using a case-control design. SETTING Two large Dutch teaching hospitals. PARTICIPANTS A 2 year old beagle trained to identify the smell of C difficile and tested on(More)
BACKGROUND Lipoatrophy is known to be associated with stavudine as part of the treatment for HIV infection, but it is less clear if this serious side effect is also related to other nucleoside reverse transcriptase inhibitors like zidovudine. We aimed to determine whether zidovudine-sparing first-line antiretroviral therapy would lead to less lipoatrophy(More)
Individual variations in susceptibility to an infection as well as in the clinical course of the infection can be explained by pathogen related factors, environmental factors, and host genetic differences. In this paper we review the state-of-the-art basic host genomic and genetic findings' translational potential of human immunodeficiency virus (HIV),(More)
It is challenging to change physicians' antimicrobial prescribing behaviour. Although antimicrobial prescribing is determined by contextual (e.g. a lack of guidelines), cultural (e.g. peer practice) and behavioural (e.g. perceived decision making autonomy) factors, most antimicrobial stewardship programmes fail to consider these factors in their approach.(More)
Medical students should be better prepared for their future role as prescribers. A new educational concept to achieve this is learning by doing. This encompasses legitimate, context-based training and gives students responsibility as early as possible in their medical education. Student-run clinics (SRCs) are an example of this concept. Describe the(More)
The aim of this study is to evaluate the effect of different levels of realism of context learning on the prescribing competencies of medical students during the clinical clerkship in internal medicine. Between 2001 and 2007, 164 medical students took part in the prospective explorative study during their clinical clerkship in internal medicine at the VU(More)
C ombination antiretroviral therapy has improved survival in human im-munodeficiency virus (HIV)-infected patients but has become associated with altered body fat distribution, type 2 diabetes , and increased cardiovascular risk (1). Both the protease inhibitors and nucleotide reverse transcriptase inhibitors have been implicated (1). Management of(More)
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