Michiaki Watanabe

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Given the plethora of well–documented breast carcinoma–associated antigens in humans including MAGE–1, –2 and –3, mutated p53, p21ras, HER–2/neu and DF3/MUC–1, coupled with evidence that humoral and cytotoxic T–cell responses against these antigens exist1–6, the central dilemma facing tumor immunologists is why the host immune response is so inefficient.(More)
BACKGROUND The angiogenic response is partly involved in the progression of encapsulating peritoneal sclerosis (EPS). However, the details of the angiogenic response, especially for lymphatic vessels in patients with EPS, remain unclear. In addition, because of technical limitations, morphology studies reported to date have examined only the parietal(More)
The aim of the present study was to investigate markers in surgically resected specimens of colorectal cancer that can be used to predict the response to chemotherapy. The mRNA expression levels of enzymes involved in 5-fluorouracil (5-FU) metabolism and folate metabolism were measured in formalin-fixed, paraffin-embedded tumor sections obtained from the(More)
Dendritic cell (DC)/tumor cell fusion cells (FCs) can induce potent CTL responses. The therapeutic efficacy of a vaccine requires the improved immunogenicity of both DCs and tumor cells. The DCs stimulated with the TLR agonist penicillin-killed Streptococcus pyogenes (OK-432; OK-DCs) showed higher expression levels of MHC class I and II, CD80, CD86, CD83,(More)
Trotter's product formula is given for nonlinear semigroups in L1 (fi^) generated by quasilinear operators of the form A<p, where 0 is a suitable function: formally exp(tA<£)u = limhjrj{exp(/iA<£i) ■ • ■ exp(hA<j>ic)}^t^h'u, where <j) = <f>\ + ■ ■ ■ + <PkThe proof is carried out by a new method for construction of a semigroup with generator Atf> in L'fr?^).
PURPOSE We report a patient with a repeated recurrent tumor after Right-hemicolectomy for advanced cecal cancer who was treated by intra-arterial infusions of 5-fluorouracil (5-FU). METHODS A computed tomography scan revealed a pelvic mass involving the psoas major muscle and quadratos lumborum muscle, in contact with the widely projecting toward L2-S2.(More)
The significance of tumor tissue thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels, as well as the TP/DPD ratio have recently been reported as prognostic factors and for custom-made chemotherapy. However, there have been no distinct studies on actual tumor sampling methods. For 16 patients who had undergone resection of advanced(More)
Human metastatic colorectal carcinomas (CRCAs) express carcinoembryonic antigen (CEA) and/or MUC1 tumor-associated antigens as potential targets for the induction of active specific immunity. In the present study, freshly isolated metastatic CRCA cells were successfully fused with immature autologous human monocyte-derived dendritic cells (DCs). The created(More)