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BACKGROUND The purpose of this experiment was to investigate mechanisms underlying commonly-observed verbal memory impairments in schizophrenia, and especially the hypothesized encoding deficit. METHODS A verbal memory task was administered to 38 patients with schizophrenia and 38 normal controls. Three functions involved in long-term memory-encoding,(More)
Understand the life cycle of a clinical study from a financial perspective Understand the purpose of an Internal Cost Assessment (ICA) and how it impacts budget negotiations Learn how revenue is earned during a clinical study life cycle Understand what type of costs are incurred and the concept of effort management Learn the importance of financial and(More)
The purpose of this study was to investigate how underlying cognitive deficits such as a defect in processing speed or in selective attention contributed to different types of memory impairment observed in schizophrenia (superficial vs deep encoding). 49 schizophrenic patients and 40 normal controls were administered a verbal memory task. Superficial(More)
OBJECTIVE The purpose of this study was to examine the relations between depression, psychomotor retardation, and negative symptoms in schizophrenia as well as the specific contribution of each of these factors to memory impairment. BACKGROUND It has been suggested that depression overlaps with negative symptomatology in schizophrenia. The relation(More)
A reality monitoring task was administered to 31 schizophrenic patients and 31 normal controls. Twenty-four items were produced, either orally by the experimenter, orally by the subjects, or seen as pictures. Subjects were later read a list of 48 items and were asked to indicate if each item was new, self-generated, experimenter-generated, or presented as a(More)
A link between slowing of processing speed and cognitive disorders, including memory, has repeatedly been found in research on aging, and suggested in other cognitively impaired populations. We tested the hypothesis that a link between memory impairment and slowing of processing speed would also be observed in schizophrenia. Forty-four schizophrenic(More)
Three neuropsychological tests (Rey's auditory verbal learning test, word fluency and signal detection test for words) were administered to 36 depressed patients (medicated and non-medicated) and 26 controls and compared to scale scores for depression severity and psychomotor retardation to examine how retardation was related to cognitive performance. As(More)
We wished to confirm and extend a previous correlational study of our group, suggesting that positive symptoms in schizophrenia were linked to an increase in certain types of memory errors, and negative symptoms to a decrease in other types of errors. A post-hoc analysis was conducted in 33 schizophrenic patients and 40 normal control subjects on memory(More)
OBJECTIVE This study investigated clinical correlates of memory impairment in schizophrenic patients. In particular, the authors hypothesized that depressive symptoms would be linked to memory efficiency, as found in other clinical populations. In addition, they tested Frith's pathophysiological model predicting links between negative symptoms and failure(More)
The purpose of this experiment was to replicate and extend to a memory task Bentall and Slade's (1985) finding that hallucinations in schizophrenic patients were linked to a liberal decision bias. A word recognition task was administered to 40 schizophrenic patients and 40 normal controls that yielded two indices of performance: an index of discrimination(More)