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The MURDOCK Study is longitudinal, large-scale epidemiological study for which participants' medication use is collected as free text. In order to maximize utility of drug data, while minimizing cost due to manual expert intervention, we have developed a generalizable approach to automatically coding medication data using RxNorm and NDF-RT and their… (More)
BACKGROUND The national mandate for health systems to transition from ICD-9-CM to ICD-10-CM in October 2015 has an impact on research activities. Clinical phenotypes defined by ICD-9-CM codes need to be converted to ICD-10-CM, which has nearly four times more codes and a very different structure than ICD-9-CM. METHODS We used the Centers for Medicare &… (More)
INTRODUCTION The ability to reproducibly identify clinically equivalent patient populations is critical to the vision of learning health care systems that implement and evaluate evidence-based treatments. The use of common or semantically equivalent phenotype definitions across research and health care use cases will support this aim. Currently, there is no… (More)
The migration of healthcare data from ICD-9-CM to ICD-10-CM in late 2015 will impact research and quality monitoring activities that rely on these codes. We used the CMS General Equivalency Mappings (GEMs) to transform a convenience sample of 32 ICD-9-CM-based phenotypes from three pragmatic trials to ICD-10-CM, using 4 different mapping strategies. We also… (More)
This paper highlights methods for using geospatial analysis to assess, enhance, and improve recruitment efforts to ensure representativeness in study populations. We apply these methods to the Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) study, a longitudinal population health study focused on the city of Kannapolis… (More)