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Intracellular recordings of cortical neurons in awake cat and monkey show a depolarized state, sustained firing, and intense subthreshold synaptic activity. It is not known what conductance dynamics underlie such activity and how neurons process information in such highly stochastic states. Here, we combine intracellular recordings in awake and naturally(More)
The optimal patterns of synaptic conductances for spike generation in central neurons is a subject of considerable interest. Ideally such conductance time courses should be extracted from membrane potential (V(m)) activity, but this is difficult because the nonlinear contribution of conductances to the V(m) renders their estimation from the membrane(More)
In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson's disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this(More)
The slow (<1 Hz) oscillation, with its alternating 'up' and 'down' states in individual neurons, is a defining feature of the electroencephalogram (EEG) during slow-wave sleep (SWS). Although this oscillation is well preserved across mammalian species, its physiological role is unclear. Electrophysiological and computational evidence from the cortex and(More)
On the use of analytic expressions for the voltage distribution to analyze intracellular recordings. Note on " Characterization of subthreshold voltage fluctuations in neuronal membranes " Abstract Different analytic expressions for the membrane potential distribution of membranes subject to synaptic noise have been proposed, and can be very helpful to(More)
Calculating event-triggered average synaptic conductances from the membrane potential.mal patterns of synaptic conductances for spike generation in central neurons is a subject of considerable interest. Ideally such conductance time courses should be extracted from membrane potential (V m) activity, but this is difficult because the nonlinear contribution(More)
Since Stanley Milgram's "six degrees of separation", the interest in the topological structure of network graphs and implications for their functional role experienced a dramatic surge. 40 years later, small-world and scale-free properties, with the latter being generally viewed as a crucial prerequisite for complex dynamical behaviours, are identified as a(More)
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