Michelle Rudolph-Lilith

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We review different aspects of the simulation of spiking neural networks. We start by reviewing the different types of simulation strategies and algorithms that are currently implemented. We next review the precision of those simulation strategies, in particular in cases where plasticity depends on the exact timing of the spikes. We overview different(More)
Intracellular recordings of cortical neurons in awake cat and monkey show a depolarized state, sustained firing, and intense subthreshold synaptic activity. It is not known what conductance dynamics underlie such activity and how neurons process information in such highly stochastic states. Here, we combine intracellular recordings in awake and naturally(More)
The optimal patterns of synaptic conductances for spike generation in central neurons is a subject of considerable interest. Ideally such conductance time courses should be extracted from membrane potential (V(m)) activity, but this is difficult because the nonlinear contribution of conductances to the V(m) renders their estimation from the membrane(More)
Event-driven simulation strategies were proposed recently to simulate integrate-and-fire (IF) type neuronal models. These strategies can lead to computationally efficient algorithms for simulating large-scale networks of neurons; most important, such approaches are more precise than traditional clock-driven numerical integration approaches because the(More)
In this computational study, we investigated (i) the functional importance of correlated basal ganglia (BG) activity associated with Parkinson's disease (PD) motor symptoms by analysing the effects of globus pallidus internum (GPi) bursting frequency and synchrony on a thalamocortical (TC) relay neuron, which received GABAergic projections from this(More)
Despite a steady improvement of computational hardware, results of numerical simulation are still tightly bound to the simulation tool and strategy used, and may substantially vary across available simulation tools or for different settings within the same simulator. Clock-driven simulation strategies proved efficient for large and highly active networks(More)
We present a new way to model the response of an electrode to an injected current. The electrode is represented by an unknown complex linear circuit, characterized by a kernel which we determine by injecting a noisy current. We show both in simulations and experiments that, when applied to a full recording setup (including acquisition board and amplifier),(More)
The slow (<1 Hz) oscillation, with its alternating 'up' and 'down' states in individual neurons, is a defining feature of the electroencephalogram (EEG) during slow-wave sleep (SWS). Although this oscillation is well preserved across mammalian species, its physiological role is unclear. Electrophysiological and computational evidence from the cortex and(More)
On the use of analytic expressions for the voltage distribution to analyze intracellular recordings. Note on " Characterization of subthreshold voltage fluctuations in neuronal membranes " Abstract Different analytic expressions for the membrane potential distribution of membranes subject to synaptic noise have been proposed, and can be very helpful to(More)