This paper addresses the problem of incorporating cognitively salient landmarks in computer-generated navigation instructions. Based on a review of the existing literature in the domain of navigation with landmarks, the paper develops algorithms for generating routing instructions that include references to landmarks. The most basic algorithm uses a new… (More)
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons. One conopeptide analogue, termed NMB-1 for noxious mechanosensation blocker 1, selectively inhibits (IC(50) 1 microM) sustained… (More)
BACKGROUND Science has developed from a solitary pursuit into a team-based collaborative activity and, more recently, into a multidisciplinary research enterprise. The increasingly collaborative character of science, mandated by complex research questions and problems that require many competencies, requires that researchers lower the barriers to the… (More)
The mechanisms for directing and organising sensory axons within developing skin remain largely unknown. The present study provides the first evidence that signalling occurs between A-ephrins and Eph-A receptors during the development of rat cutaneous sensory innervation both during normal development and following skin injury. Specifically, our data… (More)
Using RT-PCR, in situ hybridization, Western blotting, and immunofluorescence, we have analyzed the expression of neuropilin 1 (Np1) in two models of spinal cord injury (spinal cord hemisection and dorsal column crush) and following dorsal root rhizotomy in adult rats. Our results show that Np1 RNA and protein are up-regulated in the spinal cord after all… (More)
The world of "Zootopia" is a vast, multi-scale, multi-climate city that represents the biomes of the tundra, desert, rainforest, and grasslands. It is also a place where humans never existed and animals have evolved to be anthropomorphic, clothed, city-dwellers.
This panel will discuss and assess how academia and industry can articulate their visions and develop a cohesive understanding of each others roles and responsibilities in the hopes of revealing mutually beneficial protocols and guidelines to elevate both academia and industry.
Non-native fishes present a management challenge to maintaining Everglades National Park (ENP) in a natural state. We summarized data from long-term fish monitoring studies in ENP and reviewed the timing of introductions relative to water-management changes. Beginning in the early 1950s, management actions have added canals, altered wetland habitats by… (More)
Proteases regulate pathogenesis in apicomplexan parasites but investigations of proteases have been largely confined to the asexual stages of Plasmodium falciparum and Toxoplasma gondii. Thus, little is known about proteases in other Apicomplexa, particularly in the sexual stages. We screened the Eimeria tenella genome database for proteases, classified… (More)
Lighting computer generated hair is always a challenge. When that hair is 70 feet of long, beautiful, blond locks and belongs to the most famous "long haired" character in Western literature, that challenge becomes daunting. Introduce a stylized art direction that fuses the look of traditionally animated classics like Cinderella and Sleeping Beauty with the… (More)