Michelle Oppenheimer

Publications13
h-index9
Citations252
Highly Influential Citations23
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • P. Sobrado
  • 71 Publications, 662 Citations
  • D. Sanders
  • 110 Publications, 1,528 Citations
  • L. Kiessling
  • 267 Publications, 13,009 Citations
  • S. Turco
  • 235 Publications, 11,660 Citations
  • Publications
  • Influence
Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus.
UDP-galactopyranose mutase (UGM) is a flavin-containing enzyme that catalyzes the conversion of UDP-galactopyranose to UDP-galactofuranose, the precursor of galactofuranose, which is an important… Expand
  • 41
  • 5
  • PDF
Dual role of NADP(H) in the reaction of a flavin dependent N-hydroxylating monooxygenase.
Aspergillus fumigatus siderophore A (Af SidA) is a flavin-dependent monooxygenase that catalyzes the hydroxylation of ornithine, producing N(5)-hydroxyornithine. This is the first step in the… Expand
  • 30
  • 4
  • PDF
Biosynthesis of Galactofuranose in Kinetoplastids: Novel Therapeutic Targets for Treating Leishmaniasis and Chagas' Disease
Cell surface proteins of parasites play a role in pathogenesis by modulating mammalian cell recognition and cell adhesion during infection. β-Galactofuranose (Galf) is an important component of… Expand
  • 37
  • 4
  • PDF
Crystal structures of Trypanosoma cruzi UDP-galactopyranose mutase implicate flexibility of the histidine loop in enzyme activation.
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. Here we report crystal structures of the galactofuranose biosynthetic enzyme UDP-galactopyranose… Expand
  • 22
  • 3
  • PDF
Chemical Mechanism of UDP-Galactopyranose Mutase from Trypanosoma cruzi: A Potential Drug Target against Chagas' Disease
UDP-galactopyranose mutase (UGM) is a flavoenzyme that catalyzes the conversion of UDP-galactopyranose to UDP-galactofuranose, the precursor of galactofuranose (Galf). Galf is found in several… Expand
  • 35
  • 2
  • PDF
Identification of the NAD(P)H binding site of eukaryotic UDP-galactopyranose mutase.
UDP-galactopyranose mutase (UGM) plays an essential role in galactofuranose biosynthesis in microorganisms by catalyzing the conversion of UDP-galactopyranose to UDP-galactofuranose. The enzyme has… Expand
  • 22
  • 2
  • PDF
Crystal Structures and Small-angle X-ray Scattering Analysis of UDP-galactopyranose Mutase from the Pathogenic Fungus Aspergillus fumigatus*
Background: UDP-galactopyranose mutase (UGM) catalyzes a step in galactofuranose biosynthesis in pathogens and is a promising drug design target. Results: The first crystal structures and SAXS… Expand
  • 28
  • 2
  • PDF
Fluorescence Polarization Binding Assay for Aspergillus fumigatus Virulence Factor UDP-Galactopyranose Mutase
Aspergillus fumigatus is an opportunistic human pathogenic fungus responsible for deadly lung infections in immunocompromised individuals. Galactofuranose (Galf) residues are essential components of… Expand
  • 8
  • 1
  • PDF
Isolation and characterization of functional Leishmania major virulence factor UDP-galactopyranose mutase.
Human parasitic pathogens of the genus Leishmania are the causative agents of cutaneous, mucocutaneous, and visceral leishmaniasis. Currently, there are millions of people infected with these… Expand
  • 18
  • PDF
Recombinant expression, purification, and characterization of ThmD, the oxidoreductase component of tetrahydrofuran monooxygenase.
Tetrahydrofuran monooxygenase (Thm) catalyzes the NADH-and oxygen-dependent hydroxylation of tetrahydrofuran to 2-hydroxytetrahydrofuran. Thm is composed of a hydroxylase enzyme, a regulatory… Expand
  • 10
  • PDF