Michelle O. Ricks

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The inflammatory cytokine interleukin-6 (IL-6) has been linked to poor health outcomes in older adults. Oxidative stress triggers the production of IL-6, and antioxidant micronutrients play a critical role in decreasing this inflammatory response. The authors sought to identify the relations between serum levels of antioxidant nutrients and IL-6 and(More)
The relationship between specific T cell subset alterations and mortality has not been well characterized in older adults. The specific aim was to determine whether specific T cell subsets are associated with an increased risk of death. We conducted a case-control study of T cell subsets (CD4+ and CD8+ T cells, and subsets of these cells defined by(More)
OBJECTIVE We investigated the relationship of micronutrient deficiencies with the frailty syndrome in older women living in the community. METHODS Frailty status and serum micronutrients were assessed in a cross-sectional study of 754 women, 70-80 years old, from the Women's Health and Aging Studies I and II. RESULTS Among nonfrail, prefrail, and frail(More)
OBJECTIVES To determine, in disabled, older, community-dwelling women who were hospitalized, the rates and predictors of functional decline, the probability and time course of subsequent functional recovery, and predictors of functional recovery. DESIGN Population-based observational cohort. SETTING Woman's Health and Aging Study. PARTICIPANTS A(More)
BACKGROUND The role of nutritional status in the disablement process is still unclear. The objective of this study was to assess whether low concentrations of nutrients predict the development and course of disability. METHODS Longitudinal study including community-dwelling women 65 years or older enrolled in the Women's Health and Aging Study I. In(More)
BACKGROUND The relationships between denture use, malnutrition, frailty, and mortality in older women have not been well characterized. OBJECTIVE To determine whether women who use dentures and have difficulty chewing or swallowing are at higher risk of malnutrition, frailty, and mortality. DESIGN Cross-sectional and longitudinal study of 826 women,(More)
SETTING Zomba and Blantyre, Malawi, Africa. OBJECTIVES To determine whether daily micronutrient supplementation reduces the mortality of human immunodeficiency virus (HIV) infected adults with pulmonary tuberculosis (TB). DESIGN A randomised, controlled clinical trial of micronutrient supplementation for HIV-positive and HIV-negative adults with(More)
OBJECTIVES Experience Corps (EC) places older volunteers in public elementary schools in 20 cities across the country. The EC program in Baltimore is a health promotion intervention designed to improve the academic outcomes of children and increase older adult volunteer physical activity. We sought to determine if there were sustained increases in physical(More)
We characterized the erythropoietin response to anemia among 73 HIV-infected and 246 uninfected twelve-month old infants in Malawi. Among HIV-infected and uninfected infants, the fitted regression line was log10 plasma erythropoietin = 2.66 –0.011*hemoglobin, and log10 plasma erythropoietin = 2.90 –0.013*hemoglobin, respectively, and the slope of the(More)
Selenium and the carotenoids play an important role in antioxidant defenses and in the redox regulation involved in inflammation. We tested the hypothesis that low selenium and carotenoids predict mortality in older women living in the community. Women who were enrolled in the Women's Health and Aging Studies I and II in Baltimore, MD (n = 632; 70-79 y old)(More)