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OBJECTIVE We investigated the relationship of micronutrient deficiencies with the frailty syndrome in older women living in the community. METHODS Frailty status and serum micronutrients were assessed in a cross-sectional study of 754 women, 70-80 years old, from the Women's Health and Aging Studies I and II. RESULTS Among nonfrail, prefrail, and frail(More)
The relationship between specific T cell subset alterations and mortality has not been well characterized in older adults. The specific aim was to determine whether specific T cell subsets are associated with an increased risk of death. We conducted a case-control study of T cell subsets (CD4+ and CD8+ T cells, and subsets of these cells defined by(More)
AIMS To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality. METHODS We studied anemia in 688 women, >or=65 years, in the Women's Health and Aging Study I, a population based study of moderately to severely disabled older women living(More)
OBJECTIVES Experience Corps (EC) places older volunteers in public elementary schools in 20 cities across the country. The EC program in Baltimore is a health promotion intervention designed to improve the academic outcomes of children and increase older adult volunteer physical activity. We sought to determine if there were sustained increases in physical(More)
Selenium and the carotenoids play an important role in antioxidant defenses and in the redox regulation involved in inflammation. We tested the hypothesis that low selenium and carotenoids predict mortality in older women living in the community. Women who were enrolled in the Women's Health and Aging Studies I and II in Baltimore, MD (n = 632; 70-79 y old)(More)
The inflammatory cytokine interleukin-6 (IL-6) has been linked to poor health outcomes in older adults. Oxidative stress triggers the production of IL-6, and antioxidant micronutrients play a critical role in decreasing this inflammatory response. The authors sought to identify the relations between serum levels of antioxidant nutrients and IL-6 and(More)
BACKGROUND Although disabled older adults may be among the subpopulation of adults with the highest risk for adverse drug events (ADEs), reliable data on their use of medications are limited. OBJECTIVES The aims of this study were to describe the extent and patterns of medication use in community-dwelling, disabled older women, and to identify factors(More)
OBJECTIVES To determine, in disabled, older, community-dwelling women who were hospitalized, the rates and predictors of functional decline, the probability and time course of subsequent functional recovery, and predictors of functional recovery. DESIGN Population-based observational cohort. SETTING Woman's Health and Aging Study. PARTICIPANTS A(More)
INTRODUCTION Although vitamin A deficiency, iron deficiency, and inflammation may contribute to anemia, their relative contribution to anemia has not been well characterized in preschool children in developing countries. OBJECTIVE To characterize the contributions of vitamin A and iron deficiencies and inflammation to anemia among preschool children in(More)
OBJECTIVE to determine whether low serum carotenoid levels, an indicator of low intake of fruits and vegetables, are associated with the progression of disability in older women. DESIGN longitudinal analysis in a population-based cohort. SETTING moderately-severely disabled women, >or=65 years, living in the community in Baltimore, Maryland (the Women's(More)