Michelle N. Wykes

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This study identifies a dendritic cell (DC) subset that constitutively transports apoptotic intestinal epithelial cell remnants to T cell areas of mesenteric lymph nodes in vivo. Rat intestinal lymph contains two DC populations. Both populations have typical DC morphology, are major histocompatibility complex class II(hi), and express OX62, CD11c, and B7.(More)
The severity of malaria can range from asymptomatic to lethal infections involving severe anaemia and cerebral disease. However, the molecular and cellular factors responsible for these differences in disease severity are poorly understood. Identifying the factors that mediate virulence will contribute to developing antiparasitic immune responses. Since(More)
Proteins of the mammalian PYHIN (IFI200/HIN-200) family are involved in defence against infection through recognition of foreign DNA. The family member absent in melanoma 2 (AIM2) binds cytosolic DNA via its HIN domain and initiates inflammasome formation via its pyrin domain. AIM2 lies within a cluster of related genes, many of which are uncharacterised in(More)
Malaria is a significant global burden but after >30 years of effort there is no vaccine on the market. While the complex life cycle of the parasite presents several challenges, many years of research have also identified several mechanisms of immune evasion by Plasmodium spp. Recent research on malaria, has investigated the programmed cell death-1 (PD-1)(More)
The MUC1 mucin (CD227) is a cell surface mucin originally thought to be restricted to epithelial tissues. We report that CD227 is expressed on human blood dendritic cells (DC) and monocyte-derived DC following in vitro activation. Freshly isolated murine splenic DC had very low levels of CD227; however, all DC expressed CD227 following in vitro culture. In(More)
Even after years of experiencing malaria, caused by infection with Plasmodium species, individuals still have incomplete immunity and develop low-density parasitemia on re-infection. Previous studies using the P. chabaudi (Pch) mouse model to understand the reason for chronic malaria, found that mice with a deletion of programmed cell death-1 (PD-1KO)(More)
  • D G Whyte, L R Baylor, D J Campbell, R Granetz, M Gluga, R Hawryluk +5 others
  • 2008
Recent work conducted under the aegis of the US Burning Plasma Organization related to establishing recommendations for requirements for ITER disruption mitigation systems is described. The recommendations and assessments of the resulting plasma and tokamak operations impacts of a massive-gas-injection disruption mitigation system have been developed in(More)
The reference design of the ITER torus exhaust pumping system is based on 8 cryopumps, connected via 4 ducts to the torus. The exhaust gas flows will pass through the divertor into the pumping slots, at divertor pressures between 1 and 10 Pa. The pumping port and divertor geometry has limited conductance which reduces the available pumping speed for the(More)
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