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OBJECTIVE The recurrence rate of anti-SSA/Ro-associated congenital heart block (CHB) is 17%. Sustained reversal of third-degree block has never been achieved. Based on potential reduction of maternal autoantibody titers as well as fetal inflammatory responses, intravenous immunoglobulin (IVIG) was evaluated as preventive therapy for CHB. METHODS A(More)
BACKGROUND The inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) could potentially overcome or delay resistance to endocrine therapy in advanced breast cancer that is positive for hormone receptor (HR) and negative for human epidermal growth factor receptor 2 (HER2). METHODS In this randomized, placebo-controlled, phase 3 trial, we evaluated the(More)
OBJECTIVES Older people are at risk of undernutrition because of a number of physiological conditions and lifestyle factors. The purpose of this study was to explore the predictive relationship of corrected arm muscle area (CAMA) with 8-year mortality in a representative sample of older Australians. DESIGN Prospective cohort study: The Australian(More)
OBJECTIVES The purpose of this work was to assess the effect of botulinum toxin A and occupational therapy compared with occupational therapy alone on body structure, activities participation, and self-perception in a sample of children (aged 3-16 years) with hemiplegic cerebral palsy recruited from a statewide register. PATIENTS AND METHODS Participants(More)
OBJECTIVE To compare the effect of early discharge and home-based therapy with conventional hospital rehabilitation on patient and caregiver outcomes at 12 months after hip fracture. DESIGN Randomized controlled trial. SETTING Acute and subacute care with follow-up in a community setting in Australia. PARTICIPANTS Sixty-six older adults admitted to(More)
The present study investigated the scope of planning in speech production by examining onset latencies for sentences describing moving picture displays. The experimental sentences began with either a simple or complex noun phrase, but were matched in length and content words. Results from young and old normal participants replicated previous findings of(More)
OBJECTIVES To describe and characterize the prevalence and quality of pain in a population-based community sample of children with hemiplegic cerebral palsy. METHODS Outcomes were assessed from 2 domains of the World Health Organization International Classification of Functioning, Disability and Health: body structure/function (upper limb spans, modified(More)
OBJECTIVE To describe the independent and combined effects of oral nutrition supplementation and resistance training on health outcomes in nutritionally at risk older adults following lower limb fracture. DESIGN Randomized controlled trial with 12-week masked outcome assessment. SETTING Teaching hospital. PARTICIPANTS One hundred nutritionally at risk(More)
OBJECTIVE Flow-mediated dilatation (FMD) and peripheral artery tonometry (PAT) are commonly used methods for assessing endothelial function in a research setting but it is unclear how well they correlate. This study aimed to compare and correlate these methods in patients with peripheral arterial disease (PAD) and in healthy individuals. MATERIALS AND(More)
OBJECTIVE To report the dietary energy and protein intake of undernourished older adults (with and without cognitive impairment) admitted to hospital following a lower limb fracture and to determine whether dietary intakes met estimated requirements. DESIGN An observational study of a sequential sample. SETTING The orthopaedic ward of a South Australian(More)