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The research presented h e r e a d d r esses the problem of change impact analysis CIA for object-oriented software. A major problem for developers in an evolutionary environment is that seemingly small changes can ripple throughout the system to have major unintended impacts elsewhere. As a result, software developers need to understand how a change to a(More)
In intact Xenopus embryos, an increase in intracellular Ca(2+) in the dorsal ectoderm is both necessary and sufficient to commit the ectoderm to a neural fate. However, the relationship between this Ca(2+) increase and the expression of early neural genes is as yet unknown. In intact embryos, studying the interaction between Ca(2+) signaling and gene(More)
Patients with chronic diseases such as diabetes have to monitor complex sets of medical observations and behaviors. This includes blood glucose, weight, cholesterol, HbA1c, blood pressure, as well as diet, exercise and medication. We have developed a set of web-based, highly interactive graphic modules that are integrated in a personal health record to(More)
The topography of antibody binding sites has been classified into five types that evoke familiar geomorphic features of the Earth. The 229 antibody crystal structures from the Protein Data Bank were analyzed and classified into these classes. Relationships to previous topography classifications by Rees et al., who defined three classes, and Thornton et al.,(More)
In addition to genetic alterations, cancer cells are characterized by myriad epigenetic changes. EZH2 is a histone methyltransferase that is over-expressed and mutated in cancer. The EZH2 gain-of-function (GOF) mutations first identified in lymphomas have recently been reported in melanoma (~2%) but remain uncharacterized. We expressed multiple EZH2 GOF(More)
Semantic preview benefit in reading is an elusive and controversial effect because empirical studies do not always (but sometimes) find evidence for it. Its presence seems to depend on (at least) the language being read, visual properties of the text (e.g., initial letter capitalization), the type of relationship between preview and target, and as shown(More)
Insulin resistance in metabolic syndrome subjects is profound in spite of muscle insulin receptor and insulin-responsive glucose transporter (GLUT4) expression being nearly normal. Insulin receptor tyrosine kinase phosphorylation of insulin receptor substrate-1 (IRS-1) at Tyr896 is a necessary step in insulin stimulation of translocation of GLUT4 to the(More)