Michelle Ladouceur-Wodzak

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OBJECTIVE The blood-brain barrier (BBB) protects the brain by preventing the entry of large molecules; this poses a major obstacle for the delivery of drugs to the brain. A novel technique using focused ultrasound (FUS) energy combined with microbubble contrast agents has been widely used for non-invasive trans-cranial BBB opening. Traditionally, FUS(More)
3D MR neurography targeted peripheral nerve ablation with MR-guided high intensity focused ultrasound (MR-HIFU): initial results of a feasibility study in a swine model Background/introduction MR-guided HIFU is an effective treatment for metastatic bone pain through periosteal nerve ablation,[1] and is being investigated for treating back pain through facet(More)
PURPOSE Ultrasound (US)-guided high intensity focused ultrasound (HIFU) has been proposed for noninvasive treatment of neuropathic pain and has been investigated in in-vivo studies. However, ultrasound has important limitations regarding treatment guidance and temperature monitoring. Magnetic resonance (MR)-imaging guidance may overcome these limitations(More)
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