Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma.
BACKGROUND Years spent in college represents a critical time for obesity development though little information is known regarding how body weight and composition changes beyond the first year of college. The aim of this study was to investigate changes in body weight and composition and the factors influencing those changes among sophomore females. … (More)
GITR is a member of the TNFR superfamily of proteins and is expressed on resting regulatory T cells and on other T cells, and NK cells, following activation. Signals through GITR have been shown to drive increased T cell activity and reduced regulatory T cell function. In order to explore the potential of therapeutically targeting GITR in a cancer setting,… (More)