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ii ACKNOWLEDGMENTS This was a large-scale project that could not have been completed without the efforts and cooperation of many programs, agencies, and individuals. The authors wish to thank the directors and staff at the programs included in this project. They were willing to answer questionnaires, surveys, and sit through lengthy interviews to assist in(More)
Peripheral neuropathies increase with aging, and reactive oxygen species contribute to the symptomatology of neuropathic pain disorders. In this study, we examined age-related differences in the therapeutic efficacy of pre- or post-treatments of the amino-steroidal antioxidant 16-desmethyltirilazad in delaying the onset and/or limiting the duration of(More)
Measurement of improvement in clinical trials in chronic diseases commonly compares baseline data to endpoint values by performing t-tests or analysis of variance (ANOVA) on raw gains or percentage changes. This procedure can be misleading and the use of an analysis of covariance (ANCOVA) should be considered. Properly used, ANCOVA increases statistical(More)
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