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Heme sensing in Bacillus thuringiensis: a supplementary HssRS-regulated heme resistance system.
Several Gram-positive pathogens scavenge host-derived heme to satisfy their nutritional iron requirement. However, heme is a toxic molecule capable of damaging the bacterial cell. Gram-positiveExpand
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Directed evolution reveals the mechanism of HitRS signaling transduction in Bacillus anthracis
Two component systems (TCSs) are a primary mechanism of signal sensing and response in bacteria. Systematic characterization of an entire TCS could provide a mechanistic understanding of theseExpand
Directed evolution reveals the mechanism of HitRS signal transduction in Bacillus anthracis
Bacterial two component systems (TCSs) have been studied for decades; however, most work has focused on individual domains or proteins. Systematic characterization of an entire TCS could provide aExpand