Michelle L. Chaisson

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OBJECTIVE During inflammation, the serum amyloid A (SAA) content of HDL increases, whereas apolipoprotein A-I (apoA-I) and paraoxonase-1 (PON-1) decrease. It remains unclear whether SAA physically displaces apoA-I or if these changes derive from coordinated but inverse transcriptional regulation of the HDL apolipoprotein genes. Because cytokines stimulate(More)
The ␣ v ␤ 3 integrin plays a fundamental role during the angiogenesis process by inhibiting endothe-lial cell apoptosis. However, the mechanism of inhibition is unknown. In this report, we show that integrin-mediated cell survival involves regulation of nuclear factor-kappa B (NF-␬ B) activity. Different extracellu-lar matrix molecules were able to protect(More)
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