Michelle H Prickett

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Let E be an elliptic curve over a number field K. Let h be the logarithmic (or Weil) height on E and ĥ be the canonical height on E. Bounds for the difference h − ĥ are of tremendous theoretical and practical importance. It is possible to decompose h − ĥ as a weighted sum of continuous bounded functions Ψυ : E(Kυ) → R over the set of places υ of K. A(More)
Pseudomonas aeruginosa (PA) from acute and chronic (eg, cystic fibrosis (CF)) infections differ in several respects, but they can worsen prognosis in each context. Factors that facilitate conversion from an acute to chronic phenotype are poorly understood. T3 secretion proteins are virulence factors associated with poorer outcomes in acute infections, but(More)
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene and is the most common life-shortening genetic defect in Caucasians. Life expectancy in CF has improved substantially over the last 75 years because of treatments aimed at end-organ complications. Since the CFTR gene was(More)
RATIONALE Aminoglycoside (AG) resistance of Pseudomonas aeruginosa in cystic fibrosis (CF) is associated with poorer clinical outcomes and is usually due to overexpression of the efflux pump MexXY. MexXY is regulated by mexZ, one of the most commonly mutated genes in CF P. aeruginosa isolates. Little is known about the evolutionary relationship between AG(More)
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