Michelle G. Tran

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The three-dimensional structure of a RNA hairpin containing the RNA operator binding site for bacteriophage GA coat protein is presented. The phage GA operator contains the asymmetric (A-A)-U sequence motif and is capped by a four-adenine (tetra-A) loop. The uridine of the (A-A)-U motif preferentially pairs with the 5'-proximal cross-strand adenine, and the(More)
BACKGROUND Atlantic cod (Gadus morhua) is among the economically most important species in the northern Atlantic Ocean and a model species for studying development of the immune system in vertebrates. MicroRNAs (miRNAs) are an abundant class of small RNA molecules that regulate fundamental biological processes at the post-transcriptional level. Detailed(More)
Previous studies have shown that despite belonging to the same family of ColE1-type plasmids, the pUC19 plasmid is selectively maintained after a few generations when co-transformed with the pBR322 plasmids into Escherichia coli DH5α host cells. Some intrinsic differences between the pUC19 and pBR322 plasmids were proposed as potential explanations,(More)
Human genome-wide association studies (GWAS) and linkage studies have identified 695 genes associated with Alzheimer's disease (AD), the vast majority of which are associated with late-onset AD. Although orthologs of these AD genes have been studied in several model species, orthologs in the nematode, Caenorhabditis elegans, remain incompletely identified,(More)
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