Michelle Flavin

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To gain a better understanding of the nature of active chromatin in mammals, we have characterized in living cells the various chromatin modification events triggered by the glucocorticoid receptor (GR) at the rat tyrosine aminotransferase gene. GR promotes a local remodeling at a glucocorticoid-responsive unit (GRU) located 2.5 kb upstream of the(More)
A basic fraction from brain cytosol was found to contain two or more tubulin-binding proteins, able to induce aggregation of tubulin accompanied by hydrolysis of GTP. In some respects tubulin aggregation by the brain proteins was similar to its aggregation by polylysine. The burst of GTP hydrolysis accompanying tubulin aggregation by polylysine had the(More)
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