Michelle Cortes

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The effects on spontaneous ovulation associated with the unilateral or bilateral sectioning of the superior ovarian nerves (SON) were analyzed in guinea pigs at different time intervals of the estrous cycle. Day 1 of the estrous cycle was defined as the day when the animal presents complete loss of the vaginal membrane (open vagina). Subsequent phases of(More)
Background: Our laboratory recently developed two PET radioligands: 11C-PS13 for COX-1 and 11C-MC1 for COX-2, each of which potently and selectively inhibits the cognate enzyme in whole blood assays from monkey and human. Based on studies in peripheral organs, COX-1 is typically present at baseline (i.e., constitutively expressed) but not induced (i.e.,(More)
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