Michelle C Webb

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SAMHD1, an analogue of the murine interferon (IFN)-γ-induced gene Mg11 (ref. 1), has recently been identified as a human immunodeficiency virus-1 (HIV-1) restriction factor that blocks early-stage virus replication in dendritic and other myeloid cells and is the target of the lentiviral protein Vpx, which can relieve HIV-1 restriction. SAMHD1 is also(More)
A human autoantiserum (5051) directed against pericentriolar material (PCM) was used to study the distribution of microtubule-organizing centers (MTOCs) in the oocyte and during the first cell cycle of mouse development. In oocytes, the PCM was found not only at the poles of the barrel-shaped metaphase II spindle but also at many discrete loci around the(More)
The influence of mouse oocyte chromosomes on their immediate environment has been investigated following their dispersal by dissolution of the metaphase spindle with nocodazole. Small clusters of chromosomes become redistributed around the egg cortex in a microfilament-dependent process. Each cluster has the capacity, on removal from nocodazole, to organize(More)
In JCLR and Wistar-Porton rats renal concentrations of Cd2+ were maximal (21-22 micrograms Cd2+/g wet wt tissue) at 1 and 4 h respectively after the administration of CdCl2 (10 micromol, 1-12 mg Cd2+/kg body wt) together with L-cysteine (5 mmol/kg body wt). Synthesis of metallothionein in the kidney in response to the uptake of Cd2+, which occurred between(More)
Administration of Cd2+ to the 12-day pregnant rat caused a dose-dependent inhibition of placental 65Zn2+ transport. At 4 h after the injection of the teratogenic dose (1.25 mg Cd2+ per kg body weight), transport of 65Zn2+ to the embryo was inhibited by 75%. This inhibition decreased with time and at 48 h was no longer statistically significant. In contrast(More)
BACKGROUND Chronic kidney disease (CKD) is a major health problem. A better understanding of the epidemiological characteristics of the different stages of CKD and the associated adverse outcomes is needed to establish and implement appropriate management strategies. METHODS A serum creatinine (SCr) level of 2.03 mg/dL or greater (> or =180 micromol/L) in(More)
CONTEXT Screening for intimate partner violence (IPV) in health care settings has been recommended by some professional organizations, although there is limited information regarding the accuracy, acceptability, and completeness of different screening methods and instruments. OBJECTIVE To determine the optimal method for IPV screening in health care(More)
Until the 16th day of gestation the intravenous LD50 of Cd2+ in the pregnant Wistar-Porton rat is higher, but not significantly different from that (1.8 mg Cd2+ per kg body weight) in nulliparous females. At 20 days it is 1.1 mg Cd2+ kg per body weight. This decrease is related to the rapid increase in weight of the conceptuses in late gestation and to the(More)
BACKGROUND Most patients with chronic kidney disease (CKD) develop cardiovascular complications. Natriuretic peptides are novel markers that can be used to identify and monitor heart failure, but the effect of renal disease on these markers is not fully understood. The aim of the present study is to explore the relationship among circulating B-type(More)