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[177Lu-DOTA0,Tyr3]octreotate: comparison with [111In-DTPA0]octreotide in patients
TLDR
In comparison with the radionuclide-coupled somatostatin analogues that are currently available for som atostatin receptor-mediated radiotherapy, 177Lu-octreotate potentially represents an important improvement. Expand
Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development
TLDR
Examination of granulosa cell and theca cell regulated genes associated with bovine antral follicle development and identified candidate growth factors potentially involved in the regulation of cell–cell interactions required for ovarian function are identified. Expand
Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors.
TLDR
Findings show that the new NT peptide analogues are robust and can deliver imaging agents to NTR-positive tumors such as pancreatic cancer. Expand
TNFα G308A polymorphism is associated with resilience to sleep deprivation-induced psychomotor vigilance performance impairment in healthy young adults
TLDR
Evidence is provided for a role of TNFα in the effects of sleep deprivation on psychomotor vigilance performance and the TNF α G308A polymorphism may have predictive potential in a biomarker panel for the assessment of resilience to psychom motor vigilance performance impairment due to sleep deprivation. Expand
Non‐redundant inhibitor of differentiation (Id) gene expression and function in human prostate epithelial cells
TLDR
The expression and function of all four Id isoforms in prostate cancer cell lines was investigated to gain a better understanding of the role of each Id isoform in normal prostate epithelial and prostate cancer cells. Expand
Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss.
TLDR
Electroencephalographic data demonstrate that innate immune signaling pathways active in the monocyte lineage, including presumably microglia, detect and mediate in part the cerebral reaction to sleep loss. Expand
Sleep slow-wave activity regulates cerebral glycolytic metabolism.
TLDR
Cerebral SWA promotes a decline in the rate of glycolysis in the cerebral cortex, demonstrating a cellular energetic function for sleep SWA, which may contribute to its restorative effects on brain function. Expand
Influence of corticosteroids on interleukin-1β-stimulated equine chondrocyte gene expression.
TLDR
No differential effects of MPA or TA on chondrocytic gene expression were identified suggesting that any divergent influences of these glucocorticoids on chONDrocyte metabolism are posttranslational. Expand
Evidence for neuroinflammatory and microglial changes in the cerebral response to sleep loss.
TLDR
The anti-neuroinflammatory agent minocycline prevents either the buildup or expression of sleep need in rodents and is not mediated by suppression of il-1β, il-6, and tnfα at the transcript level. Expand
Cerebral microglia mediate sleep/wake and neuroinflammatory effects of methamphetamine
TLDR
It is proposed that the effects of D-METH on sleep/wake cycles are mediated in part by actions on microglia, including possibly nNOS activity and cytokine synthesis. Expand
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